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ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.
Sec. Clinical Infectious Diseases
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1492208
This article is part of the Research Topic Molecular mechanisms and clinical studies of multi-organ dysfunction in sepsis associated with pathogenic microbial infection View all 3 articles

Risk factors associated with mortality and pathogen characteristics of bloodstream infection-induced severe sepsis in the pediatric intensive care unit: a retrospective cohort study

Provisionally accepted
Chen Jian Chen Jian huang Haixin huang Haixin Zhang Ruichen Zhang Ruichen Yueqiang Fu Yueqiang Fu Jing Chunmei Jing Chunmei *
  • Chongqing Key Laboratory of Pediatrics, Children‘s Hospital of Chongqing Medical University, Chongqing, China

The final, formatted version of the article will be published soon.

    Background: Bloodstream infection (BSI)-induced severe sepsis is a common cause of mortality, frequently resulting in septic shock and multiple organ dysfunction extended-spectrum cephalosporin resistance (ECR) and fluoroquinolone resistance (FQR) in Escherichia coli (E. coli) were higher than those in Klebsiella pneumoniae.In the PICU, higher mortality was observed in children with BSI-induced severe sepsis who presented with elevated pSOFA scores and low P/F values. Acinetobacter baumannii exhibited the highest levels of CR and FQR, while Escherichia coli demonstrated the highest level of ECR.

    Keywords: Bloodstream infection, Sepsis, Risk factors, Intensive Care Units, Children, Mortality

    Received: 06 Sep 2024; Accepted: 14 Jan 2025.

    Copyright: © 2025 Jian, Haixin, Ruichen, Fu and Chunmei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jing Chunmei, Chongqing Key Laboratory of Pediatrics, Children‘s Hospital of Chongqing Medical University, Chongqing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.