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ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.
Sec. Clinical Infectious Diseases
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1446470
This article is part of the Research Topic Bacterial Meningitis: Epidemiology, Pathogenesis and Beyond View all 3 articles

Analysis of Intracranial Lesions in Patients with HIV-Associated Cryptococcal Meningitis

Provisionally accepted
Wei Song Wei Song Li Liu Li Liu Tangkai Qi Tangkai Qi Zhenyan Wang Zhenyan Wang Yang Tang Yang Tang Jianjun Sun Jianjun Sun Shuibao Xu Shuibao Xu Junyang Yang Junyang Yang Jiangrong Wang Jiangrong Wang Jun Chen Jun Chen Renfang Zhang Renfang Zhang Yinzhong Shen Yinzhong Shen *
  • Shanghai Public Health Clinical Center, Fudan University, Shanghai, China

The final, formatted version of the article will be published soon.

    Background: Intracranial imaging abnormalities are commonly observed in patients suffering from HIV-associated cryptococcal meningitis, both before and during the treatment period. This study aims to analyze the prevalence, origins, radiological characteristics, treatments, and prognosis of intracranial lesions in patients with HIVassociated cryptococcal meningitis, thereby providing references for future clinical decision-making.The clinical data of patients diagnosed with HIV-associated cryptococcal meningitis and admitted to the Shanghai Public Health Clinical Centre between 2013 and 2019 were collected. Logistic regression analysis was subsequently conducted to identify potential risk factors associated with the development of intracranial lesions in this patient group.Of 211 patients analyzed, 64.5% (136/211) had intracranial lesions during treatment and follow-up. Initial cranial imaging showed 60% had lesions pre-treatment. Throughout treatment, 32.7% (52/159) developed new or worsened lesions. Mortality rates at 2 weeks, 8 weeks, and 2 years for those with detected lesions were 3%, 7.6%, and 13.2%, respectively. Lesions were primarily caused by Cryptococcus (70.5%) and Mycobacterium (24.3%). Lacunar infarcts, especially in the basal ganglia, were the 样式定义: 普通(网站)

    Keywords: Cryptococcal meningitis, HIV, Intracranial lesions, Cerebrospinal Fluid, Cytokines

    Received: 09 Jun 2024; Accepted: 14 Jan 2025.

    Copyright: © 2025 Song, Liu, Qi, Wang, Tang, Sun, Xu, Yang, Wang, Chen, Zhang and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yinzhong Shen, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.