94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
SYSTEMATIC REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1444793
This article is part of the Research Topic Exploring Gut Neuroimmunology: focus on the enteric nervous system in health and disease View all 3 articles
Gut microbiota of patients with post-stroke depression in Chinese population:a systematic review and meta-analysis
Provisionally accepted- 1 Hunan University of Chinese Medicine, Changsha, China
- 2 The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China
Background: Evidence of changes in the composition and function of the gut microbiota (GM) in Post-stroke depression (PSD) patients is gradually accumulating.This study aimed to systematically evaluate the relationship between PSD and GM.We searched in PubMed, Web of Science, Embase, Cochrane databases,Wangfang, VIP, CBM, and CNKI from the establishment of the database to April 17, 2024, and a systematic review and meta-analysis were performed to investigate the differences of GM between patients with PSD spectrum and healthy controls (HC) or stroke spectrum.Result: 14 studies consisting a total of 1556 individuals were included in the meta-analysis. The pooled results showed that PSD spectrum demonstrated significantly increased α diversity as indexed by Chao1 index; ACE indexes; Shannon index and Simpson index as compared to HC. Additionally, stroke spectrum significantly increased α diversity as indexed by Simpson index as compared to PSD. Furthermore, The pooled estimation of relative abundance of showed that the Bacteroidota, Fusobacteriota and Pseudomonadota in PSD patients were significantly higher than those in the HC group. while the abundance of Bacillota were higher in the HC group. Moreover, significant differences in GM were observed between PSD patients and HC at the family and genus levels.This study found that the α diversity of PSD patients was higher than that of HC. Moreover, there were also differences in the distribution of GM in phylum, family, and genus. At the same time, the level of Lachnospira in PSD patients was lower than that in the stroke group.
Keywords: gut microbiome, Dysbiosis, PSD, Stroke, Depression, review
Received: 07 Jun 2024; Accepted: 17 Mar 2025.
Copyright: © 2025 Li, Zhang, Wang, Dai and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuejuan Zhang, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.