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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Virus and Host
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1516806
This article is part of the Research Topic Perspectives in Virus and Host: 2024 View all 3 articles

SERINC5 counters retroviruses and non-retroviruses

Provisionally accepted
Yue Liu Yue Liu *Jinghua Yu Jinghua Yu Chunyu Liu Chunyu Liu Xinglong Qu Xinglong Qu Xinglin Gao Xinglin Gao
  • First Affiliated Hospital of Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    SERINC5 (serine incorporator 5), a member of the serine incorporator family, has been identified as a retrovirus restriction factor that inhibits the fusion of virions with the plasma membrane, thus blocking the release of the viral core into target cells and subsequently attenuating viral infectivity. Several viruses, such as human immunodeficiency virus (HIV), murine leukemia virus (MLV), and equine infectious anemia virus (EIAV), have evolved mechanisms to antagonize the host protein SERINC5 through HIV Nef, MLV glycosylated Gag, and the EIAV S2 protein. These viral proteins degrade SERINC5 on the cell surface through the endolysosomal system.In addition to its direct antiviral ability, SERINC5 also modulates immunity to inhibit the replication of retroviruses and nonretroviruses. This review summarizes the interaction between SERINC5 and viral replication, providing a promising avenue for fighting viral diseases.

    Keywords: SERINC5, Human Immunodeficiency virus 1, retroviruses, nonretroviruses, virus-host interaction

    Received: 25 Oct 2024; Accepted: 26 Dec 2024.

    Copyright: © 2024 Liu, Yu, Liu, Qu and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yue Liu, First Affiliated Hospital of Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.