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ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1500959
This article is part of the Research Topic Impact of oral and gut microbiome on health and diseases View all 9 articles

Gut microbial composition associated with risk of premature aging in women with yin-deficiency constitution

Provisionally accepted
Yingying Zhai Yingying Zhai Jing Li Jing Li Yanqi Cao Yanqi Cao Yufei Li Yufei Li Xuejie Bao Xuejie Bao Jinfeng Liang Jinfeng Liang Qi Liu Qi Liu Yifan Xia Yifan Xia *Ruoxi Yu Ruoxi Yu *
  • Beijing University of Chinese Medicine, Beijing, China

The final, formatted version of the article will be published soon.

    Yin-deficiency constitution (YinDC) refers to a traditional Chinese medicine concept, characterized by an imbalance state that includes an imbalance in the gut microbiota, resulting from a relative deficiency of Yin fluids within the body. In recent years, it has become apparent that the composition and structure of the gut microbiota play a significant role in the aging process. The imbalance of gut microbiota in YinDC may accelerate the aging process. However, the specific gut microbiota compositions involved in the YinDC premature aging process remain unknown. Here, we conducted a study to analyze the association between the gut microbiota and premature aging in YinDC women.At the phylum level, Cyanobacteria and Synerobacteria were found exclusively in the YinDC group.At the genus level, Bacteroides, Bifidobacterium, Haemophilus, Alistipes, and Dialister were more abundant in the YinDC group. Bilophila, Eubacterium, and Aeromonas were the most significant indicators influencing YinDC premature aging. Thus, this study demonstrated that the gut microbiota was associated with premature aging in women with YinDC, potentially providing preliminary evidence and guidance for personalized anti-aging strategies.

    Keywords: Gut Microbiota, premature aging, machine learning, Traditional Chinese Medicine, Yin-deficiency constitution

    Received: 24 Sep 2024; Accepted: 10 Dec 2024.

    Copyright: © 2024 Zhai, Li, Cao, Li, Bao, Liang, Liu, Xia and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yifan Xia, Beijing University of Chinese Medicine, Beijing, China
    Ruoxi Yu, Beijing University of Chinese Medicine, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.