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ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.
Sec. Molecular Viral Pathogenesis
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1498610
This article is part of the Research Topic Advances in Understanding Livestock and Poultry Coronavirus Infections: Mechanisms, Pathogenesis, and Control Strategies View all 5 articles

Evaluating Passive Immunity in Piglets from Sows Vaccinated with a PEDV S Protein Subunit Vaccine

Provisionally accepted
Jiajia Liu Jiajia Liu 1Guangli Hu Guangli Hu 2Guangcai Ren Guangcai Ren 3Liguo Gao Liguo Gao 1Zhiqin Zhao Zhiqin Zhao 2*Rui Geng Rui Geng 2Dingli Wang Dingli Wang 3Xiao Shen Xiao Shen 3Shengjin Liu Shengjin Liu 4Feng Chen Feng Chen 4Hanqin Shen Hanqin Shen 1*
  • 1 Guangdong Enterprise Key Laboratory for Animal Health and Environmental Control，Wen’s Foodstuff Group Co. Ltd, Yunfu, China
  • 2 State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong Province, China
  • 3 Canton Biologics Co., Ltd, Guangzhou, China
  • 4 College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China

The final, formatted version of the article will be published soon.

    Porcine epidemic diarrhea virus (PEDV) is a highly contagious virus that causes severe diarrhea and high mortality in neonatal piglets. This study aimed to evaluate the immunogenicity and protective efficacy of a PEDV S protein subunit vaccine compared to a traditional inactivated vaccine. Piglets and Sows were immunized with either the subunit vaccine or an inactivated vaccine, and serum samples were collected to assess IgG and neutralizing antibody levels. Results demonstrated that the S protein subunit vaccine induced significantly higher IgG and neutralizing antibody levels in both piglets and sows compared to the inactivated vaccine. Piglets born to immunized sows were challenged with a virulent PEDV strain. Piglets from the subunit vaccine group exhibited lower viral shedding, reduced clinical symptoms, and minimal intestinal lesions. These findings suggest that the PEDV S protein subunit vaccine provides enhanced immunity and protection against PEDV, making it a promising candidate for preventing PEDV infections in swine.

    Keywords: Porcine epidemic diarrhea virus, PEDV, Spike protein, Immunogenicity, subunit vaccine

    Received: 19 Sep 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Liu, Hu, Ren, Gao, Zhao, Geng, Wang, Shen, Liu, Chen and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhiqin Zhao, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, Guangdong Province, China
    Hanqin Shen, Guangdong Enterprise Key Laboratory for Animal Health and Environmental Control，Wen’s Foodstuff Group Co. Ltd, Yunfu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.