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ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.
Sec. Molecular Viral Pathogenesis
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1494654
This article is part of the Research Topic Advances in Understanding Livestock and Poultry Coronavirus Infections: Mechanisms, Pathogenesis, and Control Strategies View all 3 articles

Isolation and Pathogenicity of a Highly Virulent Group III Porcine Getah Virus in China

Provisionally accepted
Yu Wu Yu Wu 1,2Xiaopeng Gao Xiaopeng Gao 2,3Zhanpeng Kuang Zhanpeng Kuang 1*Limiao Lin Limiao Lin 2*Hao Zhang Hao Zhang 1Lijuan Yin Lijuan Yin 2*Jiabin Hong Jiabin Hong 2*Bohua Ren Bohua Ren 2*Qunhui Li Qunhui Li 2*Lianxiang Wang Lianxiang Wang 2*
  • 1 Sun Yat-sen University, Guangzhou, China
  • 2 Wen’s Group Academy, Wen’s Foodstuffs Group Co., Ltd, Guang Dong/Xinxing, China
  • 3 South China Agricultural University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Getah virus (GETV) is a multi-host virus found in pigs, horses, and blue foxes. Clinically, GETV can cause fever, diarrhea, and reproductive disorders in pigs, representing significant threats to pig breeding. At present, few studies have examined the pathogenicity of GETV in pigs of different ages.In the present study, a new strain, named GETV-QJ, was isolated from clinically ill pigs, and the results of whole-genome sequencing and genetic evolutionary analysis illustrated that the strain belonged to group III. The strain had 93.6%-96.3% homology with other subtypes, and its homology with the same subtype strain ranged 96.5%-99%. Further studies on the pathogenicity of the virus indicated that this strain caused severe diarrhea, fever, and intestinal and lung damage in 7-day-old piglets, resulting in their death. The piglet survival rate was 0%. In pregnant sows, this strain did not cause fever, death, or abortion, but it induced viremia, which affected the farrowing performance of sows and led to reduced piglet survival. In this study, we isolated a highly virulent group III and comprehensively established a pathogenic model of GETV in piglets and sows, providing a reference and guidance for the prevention and control of this infection.

    Keywords: Getah virus, Isolation, pathogenicity, Whole-genome sequencing, piglets and sows

    Received: 11 Sep 2024; Accepted: 30 Sep 2024.

    Copyright: © 2024 Wu, Gao, Kuang, Lin, Zhang, Yin, Hong, Ren, Li and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhanpeng Kuang, Sun Yat-sen University, Guangzhou, China
    Limiao Lin, Wen’s Group Academy, Wen’s Foodstuffs Group Co., Ltd, Guang Dong/Xinxing, China
    Lijuan Yin, Wen’s Group Academy, Wen’s Foodstuffs Group Co., Ltd, Guang Dong/Xinxing, China
    Jiabin Hong, Wen’s Group Academy, Wen’s Foodstuffs Group Co., Ltd, Guang Dong/Xinxing, China
    Bohua Ren, Wen’s Group Academy, Wen’s Foodstuffs Group Co., Ltd, Guang Dong/Xinxing, China
    Qunhui Li, Wen’s Group Academy, Wen’s Foodstuffs Group Co., Ltd, Guang Dong/Xinxing, China
    Lianxiang Wang, Wen’s Group Academy, Wen’s Foodstuffs Group Co., Ltd, Guang Dong/Xinxing, China

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