Jing Xiao
1
Fuchun Wang
1
Hongxia Yan
1
Bo Wang
2
Bin Su
1*
Xiaofan Lu
1*
Tong Zhang
1*The final, formatted version of the article will be published soon.
REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Clinical Infectious Diseases
Volume 14 - 2024 |
doi: 10.3389/fcimb.2024.1485825
Memory stem CD8 + T cells in HIV/Mtb Mono-and Co-Infection: Characteristics, Implications, and Clinical significance
Provisionally accepted- 1 Department of Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, Beijing, China
- 2 Beijing Fengtai Hospital of Integrated Traditional and Western Medicine, Beijing, China
Human immunodeficiency Virus (HIV) and Mycobacterium tuberculosis (Mtb) coinfection presents a significant public health challenge worldwide. Comprehensive assessment of the immune response in HIV/Mtb co-infection is complex and challenging. CD8 + T cells play a pivotal role in the adaptive immune response to both HIV and Mtb. The differentiation of CD8 + T cells follow a hierarchical pattern, with varying degrees of exhaustion throughout the process. Memory stem T cells (TSCM cells) is at the apex of the memory T lymphocyte system, which has recently emerged as a promising target in immunotherapy. In this context, we discuss the alterations of CD8 + TSCM cells in HIV/Mtb mono-and co-infection, their implications and clinical significance, and potential for improving immunotherapy.
Keywords: HIV, Mycobacterium tuberculosis, CD8 + T cells, memory stem T cells, exhaustion
Received: 25 Aug 2024; Accepted: 13 Nov 2024.
Copyright: © 2024 Xiao, Wang, Yan, Wang, Su, Lu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bin Su, Department of Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, Beijing, China
Xiaofan Lu, Department of Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, Beijing, China
Tong Zhang, Department of Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, Beijing, China
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