Skip to main content

ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.
Sec. Microbes and Innate Immunity
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1484291
This article is part of the Research Topic Microbial infection-associated cellular injury, resulting in adaptation and death View all articles

Chemokine profile in the serum of patients with leptospirosis

Provisionally accepted
Iago H. de Miranda Mariano Iago H. de Miranda Mariano 1,2Roberta M. Blanco Roberta M. Blanco 3Camila E. De Souza Camila E. De Souza 4Geovanna S. De Freitas Geovanna S. De Freitas 1Paulo L. Ho Paulo L. Ho 5Elizabeth A. Martins Elizabeth A. Martins 6Eliete C. Romero Eliete C. Romero 3Josefa B. Da Silva Josefa B. Da Silva 1*
  • 1 Bacteriology, Butantan Institute, São Paulo, São Paulo, Brazil
  • 2 Biosciences department, Rice University, Houston, Texas, United States
  • 3 Center for Bacteriology, Adolfo Lutz Institute, Sao Paulo, Sao Paulo, Brazil
  • 4 Butantan Institute, São Paulo, São Paulo, Brazil
  • 5 Bioindustrial Division, Butantan Institute, São Paulo, São Paulo, Brazil
  • 6 Laboratory of Recombinant Biological, Butantan Institute, São Paulo, São Paulo, Brazil

The final, formatted version of the article will be published soon.

    Leptospirosis is a global zoonosis that affects more than one million people a year, with a lethality rate of around 15%. Chemokines are crucial in the immune response against Leptospira, recruiting leukocytes to the site of infection and regulating immune activity.In previous studies we have shown that CCL2, CXCL5 and CCL8 are involved in the leptospirosis process, although the mechanisms are not understood. In this study we present the frequency of Leptospira serovars in human samples. We then evaluated the profile of various chemokines in sera from patients diagnosed with leptospirosis, assessing the possible correlation between them. Moreover, we evaluated the changes in the chemokine profile on different days after the first symptoms. The frequency of the Leptospira serovars in human samples is presented. The main findings were that CCL5, CXCL5 and CXCL9 are highly expressed during leptospirosis, indicating a special role of these molecules in the immunity and pathogenesis of the disease. The correlation analysis of correlation of detected chemokines CXCL11, CXCL9, CCL3 and CCL2 helps to clarify the role of each cytokine in leptospirosis. A possible use of CCL5 as biomarker for complementary diagnosis of the disease is suggested.

    Keywords: Chemokines, Leptospirosis, diagnosis, Leptospira, Copenhageni serovar, Protein interaction

    Received: 21 Aug 2024; Accepted: 04 Oct 2024.

    Copyright: © 2024 de Miranda Mariano, Blanco, De Souza, De Freitas, Ho, Martins, Romero and Da Silva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Josefa B. Da Silva, Bacteriology, Butantan Institute, São Paulo, São Paulo, Brazil

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.