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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1483550
This article is part of the Research Topic Can Chinese Medicines Affect Diarrhea via Effects of the Intestinal Microbiota on the Renal-Intestinal Axis? View all articles

Research progress of Traditional Chinese Medicine on the treatment of diarrhea by regulating intestinal microbiota and its metabolites based on renal-intestinal axis

Provisionally accepted
Tong Zhou Tong Zhou 1,2Yifan Zhang Yifan Zhang 1,2*Zhaoyuan Li Zhaoyuan Li 1,2Chunfeng Lu Chunfeng Lu 1,2*Hong Zhao Hong Zhao 1,2*
  • 1 Jiamusi University, Jiamusi, China
  • 2 School of Pharmacy, Jiamusi University, Jiamusi, Heilongjiang Province, China

The final, formatted version of the article will be published soon.

    Intestinal microbiota and its metabolites are involved in many physiological processes of the human body and play a vital role in maintaining human health. The occurrence of kidney disease can cause intestinal microbiota imbalance, resulting in diarrhea. The change of intestinal microbiota and its metabolites content can aggravate renal function injury, which has a bidirectional regulating effect. The theory of renal-intestinal axis further clarified that the impaired renal function is related to the imbalance of intestinal microorganisms, and the impaired intestinal barrier is related to the accumulation of toxin products. Because of its unique therapeutic advantages, Traditional Chinese Medicine can treat diarrhea by enhancing the growth of beneficial bacteria, inhibiting pathogenic bacteria and immune regulation, and slow down the continuous deterioration of kidney disease. This paper focuses on the relationship between intestinal microbiota and its metabolites and diarrhea, the influence of Traditional Chinese Medicine on intestinal microbiota in the treatment of diarrhea, and the role of intestinal microbiota and its metabolites in the renal-intestinal axis. It provides a theoretical basis for Traditional Chinese Medicine to regulate intestinal microbiota and its metabolites based on the renal-intestinal axis theory to treat nephrology-induced diarrhea, and also provides a new idea and method for Traitional Chinese Medicine to treat nephrology-induced diarrhea.

    Keywords: renal-intestinal axis, traditional Chinese medicines, Diarrhea, intestinal microbiota, Metabolites of Intestinal Microbiota

    Received: 20 Aug 2024; Accepted: 09 Sep 2024.

    Copyright: © 2024 Zhou, Zhang, Li, Lu and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yifan Zhang, Jiamusi University, Jiamusi, China
    Chunfeng Lu, Jiamusi University, Jiamusi, China
    Hong Zhao, Jiamusi University, Jiamusi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.