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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Oral Microbes and Host
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1478362
This article is part of the Research Topic Impact of oral and gut microbiome on health and diseases View all 6 articles

Periodontal Bacteria Influence Systemic Diseases Through the Gut Microbiota

Provisionally accepted
MENGYING XI MENGYING XI 1Qijun Ruan Qijun Ruan 1Sulan Zhong Sulan Zhong 1*Jiatong Li Jiatong Li 1*Weijuan Qi Weijuan Qi 1*Congman Xie Congman Xie 1*Xiaoyan Wang Xiaoyan Wang 2Nuerbiya Abuduxiku Nuerbiya Abuduxiku 3*Jia Ni Jia Ni 1*
  • 1 Affiliated Stomatological Hospital, Southern Medical University, Guangzhou, China
  • 2 Longgang Ear-Nose-Throat (ENT) Hospital, Shenzhen, China
  • 3 First People's Hospital of Kashi, Kashi, Xinjiang, China

The final, formatted version of the article will be published soon.

    Many systemic diseases, including Alzheimer disease (AD), diabetes mellitus (DM) and cardiovascular disease, are associated with microbiota dysbiosis. The oral and intestinal microbiota are directly connected anatomically, and communicate with each other through the oral-gut microbiome axis to establish and maintain host microbial homeostasis. In addition to directly, periodontal bacteria may also be indirectly involved in the regulation of systemic health and disease through the disturbed gut. This paper provides evidence for the role of periodontal bacteria in systemic diseases via the oral-gut axis and the far-reaching implications of maintaining periodontal health in reducing the risk of many intestinal and parenteral diseases. This may provide insight into the underlying pathogenesis of many systemic diseases and the search for new preventive and therapeutic strategies.As the largest microbial community in the human body, the gut microbiota plays a crucial role in establishing and maintaining host physiological homeostasis. A variety of human diseases are known to be associated with dysbiosis of the gut microbiota, such as obesity, cardiovascular disease and neurological disorders (1, 2). The proposed theories of gut-liver axis, gut-brain axis, gut-lung axis, and gut-bone axis also fully illustrate the close relationship between the gut microbiota and various

    Keywords: periodontal bacteria, oral dysbiosis, gut dysbiosis, oral-gut axis, Systemic diseases, fecal microbiota transplantation

    Received: 09 Aug 2024; Accepted: 29 Oct 2024.

    Copyright: © 2024 XI, Ruan, Zhong, Li, Qi, Xie, Wang, Abuduxiku and Ni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Sulan Zhong, Affiliated Stomatological Hospital, Southern Medical University, Guangzhou, China
    Jiatong Li, Affiliated Stomatological Hospital, Southern Medical University, Guangzhou, China
    Weijuan Qi, Affiliated Stomatological Hospital, Southern Medical University, Guangzhou, China
    Congman Xie, Affiliated Stomatological Hospital, Southern Medical University, Guangzhou, China
    Nuerbiya Abuduxiku, First People's Hospital of Kashi, Kashi, Xinjiang, China
    Jia Ni, Affiliated Stomatological Hospital, Southern Medical University, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.