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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Extra-intestinal Microbiome
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1477143
This article is part of the Research Topic The Oral Microbiome and its Impact on Systemic Health: From Disease Development to Biomaterials Development View all 3 articles

Probiotics in the Management of Radiation-induced Oral Mucositis

Provisionally accepted
Yixuan Li Yixuan Li Zixia Li Zixia Li Shuhao Zheng Shuhao Zheng Xin Xu Xin Xu *
  • West China School of Stomatology, Sichuan University, Chengdu, China

The final, formatted version of the article will be published soon.

    【Abstract】Oral mucositis is a common and debilitating oral complication in head and neck cancer patients undergoing radiotherapy, resulting in diminished quality of life and potential treatment disruptions. Oral microbiota has long been recognized as a contributing factor in the initiation and progression of radiation-induced oral mucositis (RIOM). Numerous studies have indicated that the radiation-induced oral microbial dysbiosis promotes the occurrence and severity of oral mucositis.Therefore, approaches that modulate oral microbial ecology are promising for the management of RIOM. Probiotics as a relatively predicable and safe measure that modulates microecology have garnered significant interest. In this review, we discussed the correlation between RIOM and oral microbiota, with a particular focus on the efficacy of probiotics in the control of RIOM, in order to provide novel paradigm for the management of this disease.

    Keywords: Probiotics, Oral microbiota, Microbial dysbiosis, microbial ecology, head and neck cancer

    Received: 07 Aug 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Li, Li, Zheng and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xin Xu, West China School of Stomatology, Sichuan University, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.