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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Antibiotic Resistance and New Antimicrobial drugs
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1472876

The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes

Provisionally accepted
Lei Fang Lei Fang 1Ruyan Chen Ruyan Chen 1Chenyu Li Chenyu Li 1Jingjing Sun Jingjing Sun 1Ruishan Liu Ruishan Liu 2Yanhao Shen Yanhao Shen 1Xiaobing Guo Xiaobing Guo 1*
  • 1 Department of Laboratory Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
  • 2 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Incompatible plasmids play a crucial role in the horizontal transfer of antibiotic resistance in bacteria, particularly in Gram-negative bacteria, and have thus attracted considerable attention in the field of microbiological research. In the 1970s, these plasmids, housing an array of resistance genes and genetic elements, were predominantly discovered. They exhibit a broad presence in diverse host bacteria, showcasing diversity in geographic distribution and the spectrum of antibiotic resistance genes. The complex genetic structure of plasmids further accelerates the accumulation of resistance genes in Gram-negative bacteria. This article offers a comprehensive review encompassing the discovery process, host distribution, geographic prevalence, carried resistance genes, and the genetic structure of different types incompatible plasmids, including IncA, IncC, IncF, IncL, IncM, IncH, and IncP. It serves as a valuable reference for enhancing our understanding of the role of these different types of plasmids in bacterial evolution and the dissemination of antibiotic resistance.

    Keywords: Genetic Structures, Plasmids, horizontal gene transfer, Resistance genes, Genetic element

    Received: 30 Jul 2024; Accepted: 06 Nov 2024.

    Copyright: © 2024 Fang, Chen, Li, Sun, Liu, Shen and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaobing Guo, Department of Laboratory Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.