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ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Clinical Microbiology
Volume 14 - 2024 |
doi: 10.3389/fcimb.2024.1468692
Candida spp. colonization: a genotype source found in blood cultures that can become widespread
Provisionally accepted
Aina Mesquida
1,2
Pablo Martin-Rrabadan
1,2
Luis Alcalá
1,2
Almudena Burillo
1,2
Elena Reigadas
1,2
Patricia Munoz
1,2,3
Jesus Guinea
1,2,3,4*
Pilar Escribano
1,2,4*- 1 Gregorio Marañón Hospital, Madrid, Spain
- 2 Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Madrid, Spain
- 3 Network Biomedical Research Center for Respiratory Diseases, Carlos III Health Institute (ISCIII), Madrid, Madrid, Spain
- 4 Facultad HM Hospitales de Ciencias de la Salud Universidad Camilo José Cela, Madrid, Asturias, Spain
Objective: Our previous genotyping studies suggest that some anatomical locations act as reservoirs of genotypes that may cause further candidemia, since we found identical genotypes in gastrointestinal tract or catheter tip isolates and blood cultures, in contrast, we did not find blood culture genotypes in vagina samples. We observed that some genotypes can be found in blood cultures more frequently than others, some of them being called widespread genotypes because have been found in unrelated patients admitted to different hospitals. The presence of widespread genotypes may be more frequently found because of their predisposition to cause candidemia. It is unclear whether genotypes colonizing other anatomical sites different from the gastrointestinal tract can also be detected in this way; we studied C. albicans, C. parapsilosis, and C. tropicalis colonizing genotypes to assess what proportion could be found in blood cultures and the proportion of widespread genotypes.The isolates (n= 640 Candida isolates from 323 patients) studied herein were obtained from samples processed at the Clinical Microbiology and Infectious Diseases Department of the Gregorio
Keywords: Candida, Candidemia, colonization, microsatellite, genotyping
Received: 22 Jul 2024; Accepted: 14 Oct 2024.
Copyright: © 2024 Mesquida, Martin-Rrabadan, Alcalá, Burillo, Reigadas, Munoz, Guinea and Escribano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jesus Guinea, Gregorio Marañón Hospital, Madrid, Spain
Pilar Escribano, Gregorio Marañón Hospital, Madrid, Spain
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