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BRIEF RESEARCH REPORT article

Front. Cell. Infect. Microbiol.
Sec. Microbes and Innate Immunity
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1467915
This article is part of the Research Topic Comprehensive Insights into Microbial Infection: From Pathogenesis to Therapeutic solutions View all articles

Oliguria as a Diagnostic Marker of Severe Leptospirosis: A Study from the Transcarpathian Region of Ukraine Author names and affiliations

Provisionally accepted
Pavlo Petakh Pavlo Petakh 1*Oleksandr Kamyshnyi Oleksandr Kamyshnyi 2
  • 1 Uzhhorod National University, Uzhhorod, Ukraine
  • 2 Ternopil State Medical University, Ternopil, Ternopil Oblast, Ukraine

The final, formatted version of the article will be published soon.

    Leptospirosis is an emerging illness presenting a broad range of clinical manifestations, ranging from asymptomatic or mild cases to severe and fatal outcomes. Early detection is crucial for effective treatment; however, similar clinical presentations in various febrile illnesses or co-infections, along with challenges in laboratory diagnostics, can lead to misdiagnosis and severe consequences.Identifying clinical predictors for severe forms of the disease is essential in mitigating complications and reducing mortality. Consequently, we conducted a retrospective case-control study to identify clinical markers indicative of severe disease in leptospirosis patients from the Transcarpathian region.The study focused on patients admitted with clinically suspected leptospirosis, involving a total of 51 diagnosed cases, with 13 resulting in severe outcomes and death. Categorical variables were analyzed using χ 2 , revealing a mean patient age of 50 years, predominantly male (n = 36, 70.5%). Oliguria emerged as a significant independent factor associated with mortality (odds ratio [OR], 13.5; 95% confidence interval [CI], 2.56-71.12; p = 0.001). Additionally, our analysis uncovered a noteworthy increase in leptospirosis notification rates in Transcarpathian compared to Ukraine, with 150 cases out of the total 433 in Ukraine. The highest notification rates were observed in Mukachevo District and Perechyn District. These findings highlight the importance of early recognition of key clinical markers, such as oliguria, which are critical for predicting severe outcomes in leptospirosis patients. The higher notification rates in Transcarpathian regions also underscore the need for enhanced surveillance, targeted public health interventions, and timely treatment to reduce mortality in endemic areas.

    Keywords: mortality association, Oliguria, Acute Kidney Injury, Leptospirosis, predictor

    Received: 21 Jul 2024; Accepted: 11 Oct 2024.

    Copyright: © 2024 Petakh and Kamyshnyi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Pavlo Petakh, Uzhhorod National University, Uzhhorod, Ukraine

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.