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BRIEF RESEARCH REPORT article

Front. Cell. Infect. Microbiol.
Sec. Biofilms
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1458652
This article is part of the Research Topic Fighting Microbial Biofilms: Novel Therapeutics and Antibiofilm Strategies View all 9 articles

Novel Management of Pseudomonas Biofilm-Like Structures in a Post-Pneumonectomy Empyema

Provisionally accepted
Alexandra M. Gustafson Alexandra M. Gustafson 1*Carolina M. Larrain Carolina M. Larrain 2Lindsay R. Friedman Lindsay R. Friedman 2Rachel Repkorwich Rachel Repkorwich 1Karen Forrest Karen Forrest 3Ifeanyi Anidi Ifeanyi Anidi 1Kevin P. Fennelly Kevin P. Fennelly 1Shamus R. Carr Shamus R. Carr 1*
  • 1 National Institutes of Health (NIH), Bethesda, United States
  • 2 Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States
  • 3 MRC Unit The Gambia, London School of Hygiene and Tropical Medicine, University of London, Fajara, Banjul, Gambia

The final, formatted version of the article will be published soon.

    This case report suggests a novel approach to biofilm management in post-pneumonectomy patients who are at high risk of infection. Many cases are recalcitrant to surgical debridement and systemic antibiotics, often leaving patients with open chests to allow for sufficient drainage. By working to directly degrade the biofilm using DNase in the pleural space and subsequently instill antibiotic solution into the chest, patients may be able to clear a resistant infection allowing for the closure of chest and cessation of systemic antibiotics.

    Keywords: Alexandra M Gustafson: Investigation, visualization, Writing -original draft, Writing -review & editing. Carolina M Larrain: Data curation, investigation, methodology, project administration, Writing -review & editing. Ifeanyi Anidi: Conceptualization

    Received: 02 Jul 2024; Accepted: 04 Oct 2024.

    Copyright: © 2024 Gustafson, Larrain, Friedman, Repkorwich, Forrest, Anidi, Fennelly and Carr. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Alexandra M. Gustafson, National Institutes of Health (NIH), Bethesda, United States
    Shamus R. Carr, National Institutes of Health (NIH), Bethesda, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.