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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Virus and Host
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1434775
This article is part of the Research Topic Virus-Induced Autophagy in Host Cells During Viral Infections View all articles

Molecular Mechanism of Autophagy in Porcine Reproductive and Respiratory Syndrome Virus Infection

Provisionally accepted
Xiaoyong Chen Xiaoyong Chen 1*Ziding Yu Ziding Yu 2Wenfeng Li Wenfeng Li 3
  • 1 Xingzhi College, Zhejiang Normal University, Lanxi, China
  • 2 China Agricultural University, Beijing, Beijing Municipality, China
  • 3 Wenzhou Vocational College of Science and Technology, Wenzhou, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Porcine reproductive and respiratory syndrome virus (PRRSV), a significant pathogen affecting the swine industry globally, has been shown to manipulate host cell processes, including autophagy, to facilitate its replication and survival within the host. Autophagy, an intracellular degradation process crucial for maintaining cellular homeostasis, can be hijacked by viruses for their own benefit. During PRRSV infection, autophagy plays a complex role, both as a defense mechanism of the host and as a tool exploited by the virus. This review explores the current understanding of the molecular mechanisms underlying autophagy induction under PRRSV infection, its impact on virus replication, and the potential implications for disease pathogenesis and antiviral strategies. By synthesizing the latest research findings, this article aims to enhance our understanding of the intricate relationship between autophagy and PRRSV, paving the way for novel therapeutic approaches against this swine pathogen.

    Keywords: Autophagy, Porcine Reproductive and Respiratory Syndrome Virus, Viral Proteins, virus-host interaction, cellular factors

    Received: 18 May 2024; Accepted: 30 Jul 2024.

    Copyright: © 2024 Chen, Yu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaoyong Chen, Xingzhi College, Zhejiang Normal University, Lanxi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.