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REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 14 - 2024 |
doi: 10.3389/fcimb.2024.1433131
This article is part of the Research Topic Gut-Brain Axis Correlates, Mediators, and Moderators of Stress Resilience or Vulnerability View all 4 articles
Deconstruct the link between gut microbiota and neurological diseases: application of Mendelian randomization analysis
Provisionally accepted
Xinyang Hu
1*
Jingqiu Li
2*
Xinyu Tao
1
Yuming Li
1*
Mingtao Zhao
2*
Zhehui Ma
2
Bangjie Chen
1
Shuyan Sheng
1
Jiaye Tong
1*
Haibo Zhang
1*
Xiaomei Gao
1*
Bing Shen
3*- 1 First Cinical Medical College, Anhui Medical University, Hefei, Anhui Province, China
- 2 Second Clinical Medical College, Anhui Medical University, Hefei,Anhui, China
- 3 Macau University of Science and Technology, Taipa, Macao, SAR China
Background: Recent research on the gut-brain axis has deepened our understanding of the correlation between gut bacteria and the neurological system. The inflammatory response triggered by gut microbiota may be associated with neurodegenerative diseases. Additionally, the impact of gut microbiota on emotional state, known as the "Gut-mood" relationship, could play a role in depression and anxiety disorders. Results: This review summarizes recent data on the role of gut-brain axis in the pathophysiology of neuropsychiatric and neurological disorders including epilepsy, schizophrenia, Alzheimer's disease, brain cancer, Parkinson's disease, bipolar disorder and stroke. Also, we conducted a Mendelian randomization study on seven neurological disorders (Epilepsy, schizophrenia, Alzheimer's disease, brain cancer, Parkinson's disease, bipolar disorder and stroke). MR-Egger and MR-PRESSO tests confirmed the robustness of analysis against horizontal pleiotropy. Conclusions: By comparing the protective and risk factors for neurological disorders found in our research and other researchs, we can furtherly determine valuable indicators for disease evolution tracking and potential treatment targets. Future research should explore extensive microbiome genomewide association study datasets using metagenomics sequencing techniques to deepen our understanding of connections and causality between neurological disorders.
Keywords: Mendelian randomization, gut flora, neurological disorders, Single nucleotide polymorphisms, Inflammation, Genetics
Received: 15 May 2024; Accepted: 31 Oct 2024.
Copyright: © 2024 Hu, Li, Tao, Li, Zhao, Ma, Chen, Sheng, Tong, Zhang, Gao and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xinyang Hu, First Cinical Medical College, Anhui Medical University, Hefei, Anhui Province, China
Jingqiu Li, Second Clinical Medical College, Anhui Medical University, Hefei,Anhui, China
Yuming Li, First Cinical Medical College, Anhui Medical University, Hefei, Anhui Province, China
Mingtao Zhao, Second Clinical Medical College, Anhui Medical University, Hefei,Anhui, China
Jiaye Tong, First Cinical Medical College, Anhui Medical University, Hefei, Anhui Province, China
Haibo Zhang, First Cinical Medical College, Anhui Medical University, Hefei, Anhui Province, China
Xiaomei Gao, First Cinical Medical College, Anhui Medical University, Hefei, Anhui Province, China
Bing Shen, Macau University of Science and Technology, Taipa, Macao, SAR China
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