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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1431088
This article is part of the Research Topic Understanding the Role of Microbiome in Alteration of Cellular Metabolism and Cancer Development View all 5 articles

Gut Microbiome: A Novel Preventive and Therapeutic Target for Prostatic Disease

Provisionally accepted
Hongliang Cao Hongliang Cao 1Difei Zhang Difei Zhang 2Pengyu Wang Pengyu Wang 2Yishu Wang Yishu Wang 2Chengdong Shi Chengdong Shi 1Hao Wu Hao Wu 1Hao Du Hao Du 1Wenqiang Zhang Wenqiang Zhang 1Zixuan Gou Zixuan Gou 2Honglan Zhou Honglan Zhou 1*Song Wang Song Wang 1*
  • 1 Department of Urology, First Affiliated Hospital of Jilin University, Changchun, China
  • 2 Jilin University, Changchun, Hebei Province, China

The final, formatted version of the article will be published soon.

    The human gut microbiome (GM) impacts various physiological processes and can lead to pathological conditions and even carcinogenesis if homeostasis is disrupted. Recent studies have indicated a connection between the GM and prostatic disease. However, the underlying mechanisms are still unclear. This review aims to provide a summary of the existing information regarding the connection between the GM and various prostatic conditions such as chronic prostatitis/ chronic pelvic pain syndrome (CP/CPPS), benign prostatic hyperplasia (BPH), and prostate cancer (PCa). Furthermore, the review aims to identify possible pathogenic mechanisms and suggest potential ways of targeting GM to prevent and treat prostatic disease. Due to the complexity of the mechanism between GM and prostatic diseases, additional research is required to comprehend the association between the two. This will lead to more effective treatment options for prostatic disease.

    Keywords: gut microbiome, prostate cancer, Benign prostatic hyperplasia, Prostatitis, Therapy 1 Introduction

    Received: 11 May 2024; Accepted: 15 Jul 2024.

    Copyright: © 2024 Cao, Zhang, Wang, Wang, Shi, Wu, Du, Zhang, Gou, Zhou and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Honglan Zhou, Department of Urology, First Affiliated Hospital of Jilin University, Changchun, China
    Song Wang, Department of Urology, First Affiliated Hospital of Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.