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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Clinical Infectious Diseases
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1428491
This article is part of the Research Topic Clostridioides difficile Infections and Beyond View all 6 articles

Impact of HIV on HPV-related cancers in men who have sex with men: A review

Provisionally accepted
ZIXUAN ZHANG ZIXUAN ZHANG 1Yuying Xing Yuying Xing 1Siwei Zhang Siwei Zhang 2,3*Tingdan Gong Tingdan Gong 4*Wanlin Li Wanlin Li 2,3*Lanlan Wei Lanlan Wei 2,3*
  • 1 Southern University of Science and Technology, Shenzhen, China
  • 2 National Clinical Research Center for Infectious Disease, Shenzhen, China
  • 3 Shenzhen Third People’s Hospital, Shenzhen, Guangdong Province, China
  • 4 Department of Microbiology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, China

The final, formatted version of the article will be published soon.

    Co-infection with human immunodeficiency virus (HIV) significantly increases the incidence of human papillomavirus (HPV) infection and HPV-related cancers among men who have sex with men (MSM). Conversely, HPV infection can also influence HIV acquisition rates. HIV-induced immune suppression may affect chromosomal stability, gene expression, protein function and other molecular components in MSM with HPV-related cancers. Additionally, HIV infection also alters cellular mechanisms by compromising immune responses and epithelial integrity. In this review, we reviewed the influence of HIV on specific HPV-related cancers in MSM, including oropharyngeal squamous cell carcinoma, penile cancer, and anal cancer. We integrated epidemiological data from the past five years and discussed diagnosis and treatment strategies. Overall, our review offers crucial insights into the underlying molecular and cellular mechanisms of these co-infection MSM patients. Our review aims to assist future research in developing effective treatment strategies for MSM with HIV/HPV coinfection.

    Keywords: Human papillomavirus, human immunodeficiency virus, MSM, Co-infection, Cancer

    Received: 06 May 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 ZHANG, Xing, Zhang, Gong, Li and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Siwei Zhang, National Clinical Research Center for Infectious Disease, Shenzhen, 518112, China
    Tingdan Gong, Department of Microbiology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, China
    Wanlin Li, National Clinical Research Center for Infectious Disease, Shenzhen, 518112, China
    Lanlan Wei, National Clinical Research Center for Infectious Disease, Shenzhen, 518112, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.