Wenting Zhong
1
Lanzhi Yan
1*
Yingli He
1
Tianyan Chen
1*The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Clinical Infectious Diseases
Volume 14 - 2024 |
doi: 10.3389/fcimb.2024.1426960
This article is part of the Research Topic HIV/HBV and/or HCV Infections and Hepatotoxicity in Pregnant and Non-pregnant Women View all 3 articles
A high functional cure rate was induced by Pegylated Interferon alpha-2b treatment in postpartum hepatitis B e Antigen-negative women with chronic hepatitis B virus infection: an exploratory study
Provisionally accepted- 1 Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
- 2 Department of Radiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China
Background and Aims: Limited data have been reported on achieving functional cure using pegylated interferon (Peg-IFN) alpha-2b treatment for postpartum hepatitis B e Antigen (HBeAg)-negative women with chronic hepatitis B virus (HBV) infection.This study was to assess the effectiveness and safety of Peg-IFN alpha-2b in HBV postpartum women without HBeAg and identify factors linked to the functional cure.Methods: A total of 150 HBeAg-negative postpartum women were retrospectively recruited.47 patients received Peg-IFNa-2b [Peg-IFN(+) group] and 103 patients did not [Peg-IFN(-) group]. Propensity score matching (PSM) was used to adjust the baseline imbalance between the two groups. The patients were followed for at least 48 weeks. The primary endpoints were hepatitis B surface antigen(HBsAg) loss and HBsAg seroconversion at 48 weeks. Logistic regression analysis was used to assess factors associated with HBsAg loss at 48 weeks.
Keywords: HBeAg,hepatitis B e antigen, Peg-IFN alpha-2b,pegylated interferon alpha-2b, HBsAg,hepatitis B surface antigen, PSM,propensity score matching, HBV, hepatitis B virus, HCC,hepatocellular carcinoma, CHB,chronic hepatitis B
Received: 02 May 2024; Accepted: 24 Jul 2024.
Copyright: © 2024 Zhong, Yan, Zhu, Shi, He, Chen and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lanzhi Yan, Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China
Yage Zhu, Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China
Lei Shi, Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China
Tianyan Chen, Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China
Jie Zheng, Department of Radiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shanxi, China
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