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MINI REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Molecular Viral Pathogenesis
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1425547
This article is part of the Research Topic Dysregulation of the Inflammatory Host Response to Severe Acute Respiratory Syndrome Coronavirus 2 Infection View all articles

COVID-19: A Multi-Organ Perspective

Provisionally accepted
Fabiana A. Guariente Fabiana A. Guariente João Gonçalves João Gonçalves Júlia B. Gonçalves Júlia B. Gonçalves Fernando Antônio Costa Xavier Fernando Antônio Costa Xavier Daniel R. Marinowic Daniel R. Marinowic *Denise C. Machado Denise C. Machado
  • Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil

The final, formatted version of the article will be published soon.

    In this mini review, we explore the complex network of inflammatory reactions incited by SARS-CoV-2 infection, which extends its reach well beyond the respiratory domain to influence various organ systems. Synthesizing existing literature, it elucidates how the hyperinflammation observed in COVID-19 patients affects multiple organ systems leading to physiological impairments that can persist over long after the resolution of infection. By exploring the systemic manifestations of this inflammatory cascade, from acute respiratory distress syndrome (ARDS) to renal impairment and neurological sequelae, the review highlights the profound interplay between inflammation and organ dysfunction. By synthesizing recent research and clinical observations, this mini review aims to provide an overview of the systemic interactions and complications associated with COVID-19, underscoring the need for an integrated approach to treatment and management. Understanding these systemic effects is crucial for improving patient outcomes and preparing for future public health challenges.

    Keywords: SARS-CoV-21, Covid-192, hyperinflammation3, Systemic effects4, Clinical outcomes5

    Received: 30 Apr 2024; Accepted: 18 Sep 2024.

    Copyright: © 2024 Guariente, Gonçalves, Gonçalves, Antônio Costa Xavier, Marinowic and Machado. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Daniel R. Marinowic, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil

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