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ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.
Sec. Bacteria and Host
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1425388
This article is part of the Research Topic Bacteria-Host Interactions: From Infection to Carcinogenesis View all 3 articles

Global Transcriptomic network analysis of microbiota and cancerrelated cells crosstalk in the Oral-Gut-Lung Axis

Provisionally accepted
Beatriz A. Otálora-Otálora Beatriz A. Otálora-Otálora 1*César Payán-Gómez César Payán-Gómez 2Juan J. López Rivera Juan J. López Rivera 3Natalia B. Pedroza-Aconcha Natalia B. Pedroza-Aconcha 2Claudia Aristizábal-Guzmán Claudia Aristizábal-Guzmán 1Mario A. Isaza-Ruget Mario A. Isaza-Ruget 1Carlos A. Álvarez-Moreno Carlos A. Álvarez-Moreno 3
  • 1 Fundación Universitaria Sanitas, Bogotá, Colombia
  • 2 Universidad Nacional de Colombia, La paz, Colombia
  • 3 Clinica Universitaria Colombia, Bogota D.C, Colombia

The final, formatted version of the article will be published soon.

    Background: The diagnosis and treatment of lung, colon and gastric cancer through the histologic characteristics and genomic biomarkers have not had a strong impact in the mortality rates of the top three causes of death by cancer around the world. Methods: Twenty-five transcriptomic analysis (10 datasets of lung cancer, 10 datasets of gastric cancers, and 5 datasets of colon cancer) followed all our own bioinformatic pipeline based on the utilization of specialized libraries from R language, and DAVID´s gene enrichment analyses, to identify a regulatory metafirm network of transcription factors and target genes common in every type of cancer, with experimental evidence that supports its relation with the unlock of cells phenotypic plasticity for the acquisition of the hallmarks of cancer during the tumoral process, and whose regulatory function and signaling pathways involved might depend on the constant crosstalk with the microbiome network established in the oral-gut-lung axis. Results: The global transcriptomic network analysis highlights the impact of transcription factors (SOX4, TCF3, TEAD4, ETV4, and FOXM1) that might be related to stem cells programing and cancer progression, through the regulation of genes expression like cancer-cells membrane receptors that interact with several microorganisms including human T-cell leukemia virus 1 (HTLV-1), human papilloma virus (HPV), epstein-barr virus (EBV), and SARS‑CoV‑2, which can trigger MAPK, non-canonical WNT, and IFN signaling pathways, that regulate the key transcription factors overexpression during the establishment and progression of lung, colon, and gastric cancer respectively, along with the formation of the microbiome network. Conclusion: The global transcriptomic network analysis highlights the important interaction between key transcription factors in lung, colon, and gastric cancer, regulating the expression of cancer-cells membrane receptors for the interaction with the microbiome network during the tumorigenic process.

    Keywords: Transcription Factors, Transcriptional regulatory network, cancer-related cells membrane receptors, microbiota, Hallmarks of cancer, Oral-Gut-Lung Axis, Gut-Lung cancer

    Received: 29 Apr 2024; Accepted: 15 Jul 2024.

    Copyright: © 2024 Otálora-Otálora, Payán-Gómez, López Rivera, Pedroza-Aconcha, Aristizábal-Guzmán, Isaza-Ruget and Álvarez-Moreno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Beatriz A. Otálora-Otálora, Fundación Universitaria Sanitas, Bogotá, Colombia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.