AUTHOR=Sipos Dávid , Varga Adorján , Kappéter Ágnes , Halda-Kiss Bernadett , Kása Péter , Pál Szilárd , Kocsis Béla , Péterfi Zoltán 

TITLE=Encapsulation protocol for fecal microbiota transplantation

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1424376

DOI=10.3389/fcimb.2024.1424376

ISSN=2235-2988

ABSTRACT=<sec><title>Introduction</title><p><italic>Clostridioides difficile</italic> infections (CDI) continue to pose a challenge for clinicians. Fecal microbiota transplantation (FMT) is an effective treatment option in CDI. Furthermore, recent and ongoing studies suggest potential benefits of FMT in other diseases as well.</p></sec><sec><title>Methods</title><p>We would like to present a novel protocol for encapsulation of lyophilized fecal material. Our method provides with better compliance as well as improved flexibility, storage and safety.</p></sec><sec><title>Results</title><p>FMT was conducted in 28 patients with an overall success rate of 82,14% using apsules containing lyophilized stool. 16 of patients were given capsules with lessened bacteria counts. The success rate in this group was 93,75%.</p></sec><sec><title>Discussion</title><p>The results highlight the still unanswered questions about the mechanism of action and contribute to a wider use of FMT in the clinical praxis and in research. </p></sec>