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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Clinical Infectious Diseases
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1422872
This article is part of the Research Topic Neonatal Bacterial Infections View all articles

The Potential Role of Heparin-Binding Protein in Neonatal Sepsis: Research Progress

Provisionally accepted
Xiyang Chen Xiyang Chen Haiting Li Haiting Li Jie Li Jie Li Xixi Liu Xixi Liu Linlin Chen Linlin Chen Caie Chen Caie Chen Junhui Yuan Junhui Yuan Enfu Tao Enfu Tao *
  • Department of Neonatology and NICU, Wenling Maternal and Child Health Care Hospital, Wenling, China

The final, formatted version of the article will be published soon.

    Neonatal sepsis is a major global health challenge, leading to significant morbidity and mortality in newborns. The search for precise biomarkers for its early prediction in clinical settings has been ongoing, with heparin-binding protein (HBP) emerging as a promising candidate. Originating from granules in white blood cells, HBP is released into the bloodstream in response to infection and plays a pivotal role in the body's inflammatory response. Its significance extends beyond its inflammatory origins; research indicates dynamic changes in HBP levels are strongly linked to reduced inhospital mortality, offering a prognostic advantage over existing biomarkers.Furthermore, HBP has demonstrated considerable clinical utility in the early diagnosis and stratification of neonatal sepsis, suggesting its potential as a reliable blood marker for early prediction of the disease and its severity. Its application may extend to guiding the judicious use of antibiotics in treating newborns, addressing a critical aspect of neonatal care. Despite these encouraging results, the precise clinical utility of HBP for diagnosing and treating sepsis in neonates still demands further clarification through extensive research. This review delves into the current scientific understanding of HBP's contribution to diagnosing, prognosticating, and treating neonatal sepsis, while considering its future clinical applications.

    Keywords: heparin-binding protein, Neonatal sepsis, biomarker, early diagnosis, Therapeutic intervention

    Received: 24 Apr 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Chen, Li, Li, Liu, Chen, Chen, Yuan and Tao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Enfu Tao, Department of Neonatology and NICU, Wenling Maternal and Child Health Care Hospital, Wenling, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.