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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Virus and Host
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1421571
This article is part of the Research Topic Viral infection pathogenesis and pathology in nervous system View all 5 articles

Unraveling the Complex Interplay: Immunopathology and Immune Evasion Strategies of alphaviruses with emphasis on neurological implications

Provisionally accepted
Raquel D. Souza Raquel D. Souza 1José Duarte Júnior José Duarte Júnior 1Victória S. Della Casa Victória S. Della Casa 1Daniela S. Rosa Daniela S. Rosa 2Laurent Rénia Laurent Rénia 3Carla Claser Carla Claser 1,2*
  • 1 University of São Paulo, São Paulo, Brazil
  • 2 Federal University of São Paulo, São Paulo, São Paulo, Brazil
  • 3 A*STAR Infectious Disease Labs, Singapore, Singapore

The final, formatted version of the article will be published soon.

    Arthritogenic alphaviruses pose a significant public health concern due to their ability to cause joint inflammation, with emerging evidence of potential neurological consequences. In this review, we examine the immunopathology and immune evasion strategies employed by these viruses, highlighting their complex mechanisms of pathogenesis and neurological implications. We delve into how these viruses manipulate host immune responses, modulate inflammatory pathways, and potentially establish persistent infections. Further, we explore their ability to breach the blood-brain barrier, triggering neurological complications, and how co-infections exacerbate neurological outcomes. This review synthesizes current research to provide a comprehensive overview of the immunopathological mechanisms driving arthritogenic alphavirus infections and their impact on neurological health. By highlighting knowledge gaps, it underscores the need for research to unravel the complexities of virushost interactions. This deeper understanding is crucial for developing targeted therapies to address both joint and neurological manifestations of these infections.

    Keywords: Alphavirus, Chikungunya, Mayaro, Mouse, Coinfection, Nervous System

    Received: 22 Apr 2024; Accepted: 09 Jul 2024.

    Copyright: © 2024 Souza, Duarte Júnior, Della Casa, Rosa, Rénia and Claser. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Carla Claser, University of São Paulo, São Paulo, Brazil

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.