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BRIEF RESEARCH REPORT article

Front. Cell. Infect. Microbiol.
Sec. Clinical Microbiology
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1420535
This article is part of the Research Topic Non-Tuberculous Mycobacteria Infections and COVID-19 View all 5 articles

Characteristics of Lower Respiratory Tract Pathogens in Critically Ill Patients with Heatstroke: A Retrospective Multi-Center Study

Provisionally accepted
Aijia Ma Aijia Ma 1Xinyang Jin Xinyang Jin 2*Yucong Wang Yucong Wang 1*Lietao Wang Lietao Wang 1Lvyuan Shi Lvyuan Shi 1Dingyuan Wan Dingyuan Wan 1*Qin Wu Qin Wu 1Min He Min He 1Zhuo Tang Zhuo Tang 3*Jiajin Li Jiajin Li 4*Jian Wang Jian Wang 5*Guangwei Yang Guangwei Yang 6*Zhongwei Zhang Zhongwei Zhang 1Jing Yang Jing Yang 1*Bo Wang Bo Wang 1*
  • 1 Department of Critical Care Medicine, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 2 School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Taipa, Macau Region, China
  • 3 Department of Intensive Care Medicine, Zizhong County Chinese Medicine Hospital, Zizhong, Sichuan Province, China
  • 4 Department of Intensive Care Medicine, Mianyang People's Hospital, Mianyang, Sichuan Province, China
  • 5 Department of Intensive Care Medicine, Guang'an People's Hospital, Guang'an, Sichuan Province, China
  • 6 Department of Intensive Care Medicine, Huaying People's Hospital, Huaying, Sichuan Province, China

The final, formatted version of the article will be published soon.

    This retrospective multicenter study was conducted across 83 intensive care units (ICUs) in 16 cities in Sichuan, China. Critically ill patients diagnosed with heatstroke and lung infections were included in the study. Specimens from the lower respiratory tract were collected for microbiological testing, and the characteristics of the pathogens were described. A total of 462 patients diagnosed with heatstroke-related pulmonary infections were included, 134 patients (29.0%) tested positive for respiratory pathogens. The most frequently isolated strain was Klebsiella pneumoniae (34.3%), followed by Escherichia coli (28.4%), Staphylococcus aureus (20.9%). The results revealed that in the hyperthermic resistance group, there was a higher proportion of Pseudomonas aeruginosa [14(34.1%) vs 11(11.8%), p=0.002] and Stenotrophomonas maltophilia [4(9.8%) vs 1(1.1%), p=0.030] compared to the hyperthermic control group. And a higher proportion of Staphylococcus aureus [27(29.7%) vs 1(2.3%), p<0.001], were obtained during the earlier stages with elevated temperatures. Patients with Klebsiella pneumoniae (38.3±1.9°C), Staphylococcus aureus (38.5±2.2°C), and Pseudomonas aeruginosa (38.7±1.9°C) exhibited a higher temperature environment. Our study provides crucial insights into the lower respiratory tract pathogenesis of heatstroke patients, identifying key pathogens and their temperature-dependent characteristics, thus providing a foundation for future empirical treatment strategies in heatstroke.Keywords Heatstroke, Lower respiratory tract infections, High body temperature, Lung pathogenAll patients and their families gave their informed consent prior to their inclusion in the study and that details that might disclose the identity of the subjects under study have been omitted.

    Keywords: heatstroke, Lower respiratory tract infections, High Body Temperature, Lung pathogen, intensive care unit

    Received: 23 Apr 2024; Accepted: 29 Oct 2024.

    Copyright: © 2024 Ma, Jin, Wang, Wang, Shi, Wan, Wu, He, Tang, Li, Wang, Yang, Zhang, Yang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xinyang Jin, School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Taipa, Macau Region, China
    Yucong Wang, Department of Critical Care Medicine, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
    Dingyuan Wan, Department of Critical Care Medicine, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
    Zhuo Tang, Department of Intensive Care Medicine, Zizhong County Chinese Medicine Hospital, Zizhong, Sichuan Province, China
    Jiajin Li, Department of Intensive Care Medicine, Mianyang People's Hospital, Mianyang, Sichuan Province, China
    Jian Wang, Department of Intensive Care Medicine, Guang'an People's Hospital, Guang'an, Sichuan Province, China
    Guangwei Yang, Department of Intensive Care Medicine, Huaying People's Hospital, Huaying, Sichuan Province, China
    Jing Yang, Department of Critical Care Medicine, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
    Bo Wang, Department of Critical Care Medicine, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

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