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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1416739
This article is part of the Research Topic Interaction of Microbiota and Metabolomic Disorders View all 7 articles

From Gut to Bone: Deciphering the Impact of Gut Microbiota on Osteoporosis Pathogenesis and Management

Provisionally accepted
Linjie Hao Linjie Hao Yuzhu Yan Yuzhu Yan Guilin Huang Guilin Huang Hui Li Hui Li *
  • Xi'an Honghui Hospital, Xi'an, China

The final, formatted version of the article will be published soon.

    Osteoporosis (OP) is characterized by decreased bone mineral density (BMD) and increased fracture risk, poses a significant global health burden. Recent research has shed light on the bidirectional relationship between gut microbiota (GM) and bone health, presenting a novel avenue for understanding OP pathogenesis and developing targeted therapeutic interventions. This review provides a comprehensive overview of the GM-bone axis, exploring the impact of GM on OP development and management. We elucidate established risk factors and pathogenesis of OP, delve into the diversity and functional changes of GM in OP. Furthermore, we examine experimental evidence and clinical observations linking alterations in GM composition or function with variations in BMD and fracture risk. Mechanistic insights into microbial mediators of bone health, such as microbial metabolites and products, are discussed. Therapeutic implications, including GM-targeted interventions and dietary strategies, are also explored. Finally, we identify future research directions and challenges in translating these findings into clinical practice.

    Keywords: Osteoporosis, Gut Microbiota, Risk factors, short-chain fatty acids, fecal microbiota transplantation, Therapeutic interventions

    Received: 13 Apr 2024; Accepted: 06 Sep 2024.

    Copyright: © 2024 Hao, Yan, Huang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hui Li, Xi'an Honghui Hospital, Xi'an, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.