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ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.
Sec. Virus and Host
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1414827

Identification of porcine PARP11 as a restricted factor for pseudorabies virus

Provisionally accepted
Chunyun Qi Chunyun Qi *Dehua Zhao Dehua Zhao *Xi Wang Xi Wang *Lanxin Hu Lanxin Hu *Yao Wang Yao Wang *Heyong Wu Heyong Wu *Feng Li Feng Li *Jian Zhou Jian Zhou *Tianyi Zhang Tianyi Zhang *Aosi Qi Aosi Qi *Yiran Huo Yiran Huo *Qiuse Tu Qiuse Tu *Hongming Yuan Hongming Yuan Dongmei Lv Dongmei Lv *Shouqing Yan Shouqing Yan Hongsheng Ouyang Hongsheng Ouyang Daxin Pang Daxin Pang *Zicong Xie Zicong Xie *
  • Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    PRV infection in swine can cause devastating disease and pose a potential threat to humans. Advancing the interplay between PRV and host is essential to elucidate the pathogenic mechanism of PRV and identify novel anti-PRV targets. In this study, we identified PARP11 as a host factor that can significantly affect PRV infection. Inhibition of PARP11 and knockout of PARP11 can significantly promoted PRV infection. Subsequently, we further found that PARP11 knockout upregulated the transcription of NXF1 and CRM1, resulting in enhanced transcription of viral genes. Furthermore, we also found that PARP11 knockout could activate the autophagy pathway and suppress the mTOR pathway during PRV infection. These findings could provide insight into the mechanism in which PARP11 participated during PRV infection and offer a potential target to develop anti-PRV therapies.

    Keywords: PARP11, prv, mRNA export, Autophagy, host factor

    Received: 09 Apr 2024; Accepted: 13 Sep 2024.

    Copyright: © 2024 Qi, Zhao, Wang, Hu, Wang, Wu, Li, Zhou, Zhang, Qi, Huo, Tu, Yuan, Lv, Yan, Ouyang, Pang and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Chunyun Qi, Jilin University, Changchun, China
    Dehua Zhao, Jilin University, Changchun, China
    Xi Wang, Jilin University, Changchun, China
    Lanxin Hu, Jilin University, Changchun, China
    Yao Wang, Jilin University, Changchun, China
    Heyong Wu, Jilin University, Changchun, China
    Feng Li, Jilin University, Changchun, China
    Jian Zhou, Jilin University, Changchun, China
    Tianyi Zhang, Jilin University, Changchun, China
    Aosi Qi, Jilin University, Changchun, China
    Yiran Huo, Jilin University, Changchun, China
    Qiuse Tu, Jilin University, Changchun, China
    Dongmei Lv, Jilin University, Changchun, China
    Daxin Pang, Jilin University, Changchun, China
    Zicong Xie, Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.