The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Virus and Host
Volume 14 - 2024 |
doi: 10.3389/fcimb.2024.1414827
Identification of porcine PARP11 as a restricted factor for pseudorabies virus
Provisionally accepted- Jilin University, Changchun, China
PRV infection in swine can cause devastating disease and pose a potential threat to humans. Advancing the interplay between PRV and host is essential to elucidate the pathogenic mechanism of PRV and identify novel anti-PRV targets. In this study, we identified PARP11 as a host factor that can significantly affect PRV infection. Inhibition of PARP11 and knockout of PARP11 can significantly promoted PRV infection. Subsequently, we further found that PARP11 knockout upregulated the transcription of NXF1 and CRM1, resulting in enhanced transcription of viral genes. Furthermore, we also found that PARP11 knockout could activate the autophagy pathway and suppress the mTOR pathway during PRV infection. These findings could provide insight into the mechanism in which PARP11 participated during PRV infection and offer a potential target to develop anti-PRV therapies.
Keywords: PARP11, prv, mRNA export, Autophagy, host factor
Received: 09 Apr 2024; Accepted: 13 Sep 2024.
Copyright: © 2024 Qi, Zhao, Wang, Hu, Wang, Wu, Li, Zhou, Zhang, Qi, Huo, Tu, Yuan, Lv, Yan, Ouyang, Pang and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chunyun Qi, Jilin University, Changchun, China
Dehua Zhao, Jilin University, Changchun, China
Xi Wang, Jilin University, Changchun, China
Lanxin Hu, Jilin University, Changchun, China
Yao Wang, Jilin University, Changchun, China
Heyong Wu, Jilin University, Changchun, China
Feng Li, Jilin University, Changchun, China
Jian Zhou, Jilin University, Changchun, China
Tianyi Zhang, Jilin University, Changchun, China
Aosi Qi, Jilin University, Changchun, China
Yiran Huo, Jilin University, Changchun, China
Qiuse Tu, Jilin University, Changchun, China
Dongmei Lv, Jilin University, Changchun, China
Daxin Pang, Jilin University, Changchun, China
Zicong Xie, Jilin University, Changchun, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.