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SYSTEMATIC REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1414196

Global research trends on the links between gut microbiota and radiotherapy: A bibliometric analysis (2004-2023)

Provisionally accepted
Shuyuan Wang Shuyuan Wang 1,2ZHEN YUAN ZHEN YUAN 2Xiaohui Gao Xiaohui Gao 1,3Jiaxing Wu Jiaxing Wu 1Yifan Ren Yifan Ren 1,2Xiufeng Yu Xiufeng Yu 4Jianxiong Li Jianxiong Li 2Wei Wei Wei Wei 2*
  • 1 School of Medicine, Nankai University, Tianjin, China
  • 2 Department of Radiotherapy, Chinese PLA General Hospital, Beijing, China
  • 3 Graduate School, Hebei North University, Zhangjiakou, Hebei Province, China
  • 4 Tuberculosis Hospital of Shaanxi Province, Xi'an, China

The final, formatted version of the article will be published soon.

    Background: There is a crosstalk between gut microbiota and radiotherapy. The aim of this study is to use bibliometric analysis to explore the research status and development trends of research on gut microbiota and radiotherapy.A literature search regarding publications on gut microbiota and radiotherapy from 2004 to 2023 was retrieved. CiteSpace and VOSviewer were used to conduct the bibliometric analysis. The growth rate of publications, leading countries and institutions, preferred journals, top authors and cocited authors, top co-cited references, keywords and citation were analyzed in this study.Results: A total of 2821 papers were extracted. The number of papers has increased rapidly over the past decade, especially after 2017. The USA and China had the most publications and made great contributions to this field. The Chinese Academy of Sciences stood out as the institution with the highest number of publications, followed by the Chinese Academy of Medical Sciences & Peking Union Medical College. The most influential authors were Fan Saijun and Li Yuan. PLoS One had the most publications and the most total citations. Highly cited papers and high-frequency keywords illustrated the current status and trends. Furthermore, analysis of keyword with burst revealed that immunotherapy, acid, intestinal barrier, therapy, immunotherapy, fecal microbiota transplantation, etc, are at the forefront of research in this area.This study provides an overview of research on gut microbiota and radiotherapy, highlighting influential contributors, impactful publications, and emerging trends. Our finding suggests avenues for further exploration to improve clinical outcomes.

    Keywords: Gut Microbiota, Cancer, Radiotherapy, radiosensitivity, Gut-organ axis

    Received: 08 Apr 2024; Accepted: 12 Jul 2024.

    Copyright: © 2024 Wang, YUAN, Gao, Wu, Ren, Yu, Li and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wei Wei, Department of Radiotherapy, Chinese PLA General Hospital, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.