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SYSTEMATIC REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1410506

Risk factors for inflammatory bowel disease: an umbrella review

Provisionally accepted
Rui Qian Rui Qian 1*Jiamei Zhuang Jiamei Zhuang 2Jin Tu Jin Tu 1Xiang Lu Xiang Lu 1Honghui Cheng Honghui Cheng 1子琛 欧阳 子琛 欧阳 1Xianhua Liu Xianhua Liu 1Tingping Wu Tingping Wu 1
  • 1 Shenzhen Bao'an Traditional Chinese Medicine Hospital, Shenzhen, China
  • 2 The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, 518033, China, Shenzhen, China

The final, formatted version of the article will be published soon.

    Inflammatory bowel disease (IBD) represents a cluster of chronic idiopathic inflammatory disorders situated at the nexus of intricate interplays. The primary aim of the present investigation is to perform an umbrella review of meta-analyses, systematically offering a comprehensive overview of the evidence concerning risk factors for IBD. To achieve this, we searched reputable databases, including PubMed, Embase, Web of Science, and the Cochrane Database of Systematic Reviews, from inception through April 2023. Two authors independently assessed the methodological quality of each meta-analysis using the AMSTAR tool and adhered to evidence classification criteria. In total, we extracted 191 unique risk factors in meta-analyses, including 92 significantly associated risk factors. The top ten risk factors were human cytomegalovirus (HCMV) infection, IBD family history, periodontal disease, poliomyelitis, campylobacter species infection, hidradenitis suppurativa, psoriasis, use of proton pump inhibitors, chronic obstructive pulmonary disease, and western dietary pattern. In conclusion, this umbrella review extracted 62 risk factors and 30 protective factors, most of which were related to underlying diseases, personal lifestyle and environmental factors. The findings in this paper help to develop better prevention and treatment measures to reduce the incidence of IBD, delay its progression, and reduce the burden of IBDrelated disease worldwide.

    Keywords: inflammatory bowel disease, risk factor, Umbrella review, Meta-analysis, IBD

    Received: 01 Apr 2024; Accepted: 21 Nov 2024.

    Copyright: © 2024 Qian, Zhuang, Tu, Lu, Cheng, 欧阳, Liu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Rui Qian, Shenzhen Bao'an Traditional Chinese Medicine Hospital, Shenzhen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.