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ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1408581
This article is part of the Research Topic Interaction of Microbiota and Metabolomic Disorders View all 4 articles

Role of gut microbiota and metabolomics in the lipid-lowering efficacy of statins among Chinese patients with coronary heart disease and hypercholesterolemia

Provisionally accepted
Lihua Hu Lihua Hu 1Boxian Hu Boxian Hu 2Long Zhang Long Zhang 1Yuhong Hu Yuhong Hu 2Yali Zhang Yali Zhang 3Ruihang Zhang Ruihang Zhang 2Hongxi Yu Hongxi Yu 2Dan Liu Dan Liu 2Xiaolei Wang Xiaolei Wang 2Ouya Lin Ouya Lin 2Yanjun Gong Yanjun Gong 1Yan Zhang Yan Zhang 1Cheng Li Cheng Li 2Jianping Li Jianping Li 1*
  • 1 First Hospital, Peking University, Beijing, China
  • 2 Beihang University, Beijing, Beijing Municipality, China
  • 3 Peking University, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Background: Statins, being the primary pharmacological intervention for hypercholesterolemia, exhibit a notable degree of interpatient variability in their effectiveness, which may be associated with gut microbiota. This study sought to identify the biomarkers for evaluating differences in statin efficacy.A quasi case-control study was conducted among participants with hypercholesterolemia and coronary heart disease taking rosuvastatin essential. According to the level of low density lipoprotein cholesterol (LDL-C), participants was divided into the "Up to standard" (US) group and the "Below standard" (BS) group. 16S rDNA sequencing and untargeted metabolomics were applied to detected the information of gut microbiota and related metabolites.Results: A total of 8 US and 8 BS group matched by age and sex were included in the final analysis. 16S rDNA sequencing results indicated that the characteristic strains of the US group were f-Eubacterium_coprostanoligenes and g-Papillibacter, while the characteristic flora of the BS group were o-C0119, g-Pseudolabrys, s-Dyella-Marensis and f-Xanthobacaceae. Metabolomic results suggested that the levels of chenodeoxycholic acid-3-β-D-glucuronide, 1methylnicotinamide and acetoacetate in stool samples of the US group were significantly higher than those of the BS group. By identifying the differentially abundant bacterial taxa, the gut microbiota could modulate the efficacy of statins through producing enzymes involved in cholesterol metabolism.The findings suggest that the difference in statin efficacy may be related to gut microbiota strains that can produce short-chain fatty acids and secondary bile acids and affect the efficacy of statins by regulating the activities of cholesterol metabolite-related proteins.Metabolites related to short-chain fatty acids and secondary bile acids in the gut are expected to be biomarkers indicating the efficacy of statins.

    Keywords: Gut microbiota and hypercholesterolemia Hypercholesteremia, Statins, Gut Microbiota, Metabolomics, biomarker

    Received: 22 Apr 2024; Accepted: 01 Jul 2024.

    Copyright: © 2024 Hu, Hu, Zhang, Hu, Zhang, Zhang, Yu, Liu, Wang, Lin, Gong, Zhang, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jianping Li, First Hospital, Peking University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.