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REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Veterinary and Zoonotic Infection
Volume 14 - 2024 |
doi: 10.3389/fcimb.2024.1408407
Brucella mediates autophagy, inflammation, and apoptosis to escape host killing
Provisionally accepted- 1 Southwest University, Chongqing, Chongqing Municipality, China
- 2 Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Hebei Province, China
- 3 Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, China
Brucellosis is a serious zoonosis caused by Brucella spp. infection, which not only seriously jeopardizes the health of humans and mammals, but also causes huge economic losses to the livestock industry. Brucella is a Gram-negative intracellular bacterium that relies primarily on its virulence factors and a variety of evolved survival strategies to replicate and proliferate within cells. Currently, the mechanisms of autophagy, inflammation, and apoptosis in Brucella-infected hosts are not fully understood and require further research and discussion. This review focuses on the relationship between Brucella and autophagy, inflammation, and apoptosis to provide the scientific basis for revealing the pathogenesis of Brucella.
Keywords: Brucella1, Intracellular survival2, autophagy3, inflammation4, apoptosis5
Received: 28 Mar 2024; Accepted: 26 Sep 2024.
Copyright: © 2024 Qin, Zhou, Jiao, Cheng, Meng, Wang, Wu, Fan, Li, Zhou, Chu and Jiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fengyuan Jiao, Southwest University, Chongqing, 400715, Chongqing Municipality, China
Chuan Cheng, Southwest University, Chongqing, 400715, Chongqing Municipality, China
Chi Meng, Southwest University, Chongqing, 400715, Chongqing Municipality, China
Lingjie Wang, Southwest University, Chongqing, 400715, Chongqing Municipality, China
Shengping Wu, Southwest University, Chongqing, 400715, Chongqing Municipality, China
Cailiang Fan, Southwest University, Chongqing, 400715, Chongqing Municipality, China
Jixiang Li, Southwest University, Chongqing, 400715, Chongqing Municipality, China
Bo Zhou, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, Hebei Province, China
Yuefeng Chu, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu Province, China
Hanwei Jiao, Southwest University, Chongqing, 400715, Chongqing Municipality, China
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