Skip to main content

ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1406132
This article is part of the Research Topic Gut Microbiota and Gastrointestinal Disorders - Volume II View all 6 articles

Causal Relationship Between Gut Microbiota and Insulin-like Growth Factor 1: A bidirectional two-sample Mendelian randomization study

Provisionally accepted
Xuejie Zheng Xuejie Zheng 1*Yuping Qian Yuping Qian 2Lili Wang Lili Wang 1*
  • 1 First Affiliated Hospital of Anhui Medical University, Hefei, China
  • 2 Department of Neonatology, Anhui Provincial Children's Hospital, Hefei, Anhui Province, China

The final, formatted version of the article will be published soon.

    The causal relationship between gut microbiota and insulin-like growth factor 1 (IGF-1) remains unclear. The purpose of this study was to explore the causal relationship between gut microbiota and IGF-1 in men and women.Methods: Single nucleotide polymorphisms (SNPs) related to gut microbiota were derived from pooled statistics from large genome-wide association studies (GWAS) published by the MiBioGen consortium. Pooled data for IGF-1 were obtained from a large published GWAS.We conducted Mendelian Randomization (MR) analysis, primarily using the Inverse Variance Weighted (IVW) method. Additionally, we performed sensitivity analyses to enhance the robustness of our results, focusing on assessing heterogeneity and pleiotropy.In forward MR analysis, 11 bacterial taxa were found to have a causal effect on IGF-1 in men; 14 bacterial taxa were found to have a causal effect on IGF-1 in women (IVW, all P<0.05). After FDR correction, all bacterial traits failed to pass the FDR correction. In reverse MR analysis, IGF-1 had a causal effect on 9 bacterial taxa in men, and 2 bacterial taxa in women respectively (IVW, all P<0.05).After FDR correction, the causal effect of IGF-1 on order. Actinomycetales (PFDR=0.049) remains in men. The robustness of the IVW results was further confirmed after heterogeneity and pleiotropy analysis.Our study demonstrates a bidirectional causal link between the gut microbiota and IGF-1, in both men and women.

    Keywords: Gut Microbiota, IGF-1, snps, genome-wide association studies, Mendelian randomization

    Received: 30 Mar 2024; Accepted: 29 Aug 2024.

    Copyright: © 2024 Zheng, Qian and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xuejie Zheng, First Affiliated Hospital of Anhui Medical University, Hefei, China
    Lili Wang, First Affiliated Hospital of Anhui Medical University, Hefei, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.