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ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.
Sec. Virus and Host
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1392491

Clinical features and outcomes in kidney transplant recipients with COVID-19 pneumonia: a single center retrospective cohort study

Provisionally accepted
Liang Xu Liang Xu 1Xiu Xiu Chen Xiu Xiu Chen 1*Xuying Yang Xuying Yang 2*Song Chen Song Chen 3*Yuan Zehua Yuan Zehua 1*Yuan Zehua Yuan Zehua 1Rentian Chen Rentian Chen 1*Jianli Wang Jianli Wang 1,4*Hongtao Jiang Hongtao Jiang 1*Jian Xu Jian Xu 1*Yi Wang Yi Wang 1*
  • 1 Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China
  • 2 Hugobiotech Co. Ltd., Beijing, China
  • 3 Hainan Affiliated Hospital of Hainan Medical University, haokou, China
  • 4 Tianjin First Central Hospital, Tianjin, China

The final, formatted version of the article will be published soon.

    Objective: This retrospective cohort study aimed to assess the clinical features, treatment outcomes, and short-term prognosis in kidney transplant recipients (KTRs) with concurrent coronavirus disease 2019 (COVID-19) pneumonia.Methods: KTRs with COVID-19 pneumonia who were admitted to our hospital from December 28, 2022, to March 28, 2023 were included in the study. Their clinical symptoms, responses to antiviral medications, and short-term prognosis were analyzed.Results: A total of 64 KTRs with initial diagnosis of COVID-19 pneumonia were included in this study. The primary symptoms were fever, cough, and myalgia, with an incidence of 79.7%, 89.1%, and 46.9%, respectively. The administration of antiviral drugs (paxlovid or molnupiravir) within 1-5 days and for over 5 days demonstrated a statistically significant reduction in viral shedding time compared to the group without antiviral medication (P=0.002). Both the paxlovid and molnupiravir treatment groups exhibited a significantly shorter duration of viral shedding time in comparison to the group without antiviral drugs (P=0.002). After 6 months of recovery, there was no significantly negative impact on transplant kidney function (P=0.294).Fever, cough, and myalgia remain common initial symptoms of concurrent COVID-19 pneumonia in KTRs. Early use of antiviral drugs (paxlovid or molnupiravir) is associated with better therapeutic outcomes. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had a limited impact on the short-term renal function of the KTRs with concurrent moderate or severe COVID-19 pneumonia.

    Keywords: Kidney transplant, COVID-19 pneumonia, PAXLOVID, Molnupiravir, prognosis

    Received: 10 May 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Xu, Xiu Chen, Yang, Chen, Zehua, Zehua, Chen, Wang, Jiang, Xu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiu Xiu Chen, Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China
    Xuying Yang, Hugobiotech Co. Ltd., Beijing, China
    Song Chen, Hainan Affiliated Hospital of Hainan Medical University, haokou, China
    Yuan Zehua, Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China
    Rentian Chen, Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China
    Jianli Wang, Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China
    Hongtao Jiang, Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China
    Jian Xu, Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China
    Yi Wang, Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China

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