AUTHOR=Zhang Lei , Yu Fei , Zhang Yue , Li Peifeng 

TITLE=Implications of lncRNAs in Helicobacter pylori-associated gastrointestinal cancers: underlying mechanisms and future perspectives

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1392129

DOI=10.3389/fcimb.2024.1392129

ISSN=2235-2988

ABSTRACT=<p><italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) is a harmful bacterium that is difficult to conveniently diagnose and effectively eradicate. Chronic <italic>H. pylori</italic> infection increases the risk of gastrointestinal diseases, even cancers. Despite the known findings, more underlying mechanisms are to be deeply explored to facilitate the development of novel prevention and treatment strategies of <italic>H. pylori</italic> infection. Long noncoding RNAs (lncRNAs) are RNAs with more than 200 nucleotides. They may be implicated in cell proliferation, inflammation and many other signaling pathways of gastrointestinal cancer progression. The dynamic expression of lncRNAs indicates their potential to be diagnostic or prognostic biomarkers. In this paper, we comprehensively summarize the processes of <italic>H. pylori</italic> infection and the treatment methods, review the known findings of lncRNA classification and functional mechanisms, elucidate the roles of lncRNAs in <italic>H. pylori</italic>-related gastrointestinal cancer, and discuss the clinical perspectives of lncRNAs.</p>