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ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.
Sec. Biofilms
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1383680

Novel Antimicrobial Coating For Hernia Meshes

Provisionally accepted
Klaus Dieter Kühn Klaus Dieter Kühn 1,2*Débora Coraça-Huber Débora Coraça-Huber 3,4Michael Erdtmann Michael Erdtmann 5Gerwin Bernhardt Gerwin Bernhardt 6,7Christian Fölsch Christian Fölsch 8
  • 1 University of Graz, Graz, Styria, Austria
  • 2 Department of Orthopedic and Traumatology, Medical University of Graz, Graz, Styria, Austria
  • 3 University of Innsbruck, Innsbruck, Tyrol, Austria
  • 4 Innsbruck Medical University, Innsbruck, Tyrol, Austria
  • 5 Hemotec GmbH, Würselen, Germany
  • 6 Medical University of Graz, Graz, Styria, Austria
  • 7 Department of Surgery, Medical University of Graz, Graz, Styria, Austria
  • 8 University Medical Center Giessen, Giessen, Germany

The final, formatted version of the article will be published soon.

    Methods: The meshes were coated with gentamicin palmitate, chlorhexidine palmitic acid and chlorhexidine palmitate. electron microscopy.Results: 1. Certain uniformity was observed on the quantity of chlorhexidine coating the surface of each mesh used when compared with gentamicin palmitate coating. 2.We did not detect significant difference between the amounts of gentamicin palmitate released from each mesh. 3. The release of chlorhexidine palmitate and chlorhexidine palmitic acid from UltraPro TM and Mersilene TM were The coating mass and subsequent in vitro delivery rate were evaluated for gentamicin palmitate by fluorescence polarization For Chlorhexidine coated devices the coating mass was determined by weighing the in vitro delivery rate was determined by UV absorption. The interaction of each mesh to the different coating substances was observed by scanning significantly higher (p<0.05) in comparison with the other two meshes. 4. The coating substances covered the surface of the fibers without damaging its structure. 5. The coating substances were distributed all along the fibers in all samples.We suggest the use of chlorhexidine palmitate and chlorhexidine palmitic acid, as well as gentamicin palmitate, for coating of hernia meshes aiming prevention of infections. Further investigation of the bactericidal effect of coated hernia meshes against biofilm form of S. aureus and other devicerelated infections is suggested.

    Keywords: Christian Fölsch: Conceptualization, methodology, project administration, Writing -review & editing. Débora Coraça-Huber: Formal Analysis, Writing -review & editing. Klaus Dieter Kühn: Writing -original draft, Writing -review & editing. Martin Erdtmann: Investigation, supervision, Writing -review & editing. Gerwin Bernhardt: Formal Analysis

    Received: 09 Apr 2024; Accepted: 28 Jun 2024.

    Copyright: © 2024 Kühn, Coraça-Huber, Erdtmann, Bernhardt and Fölsch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Klaus Dieter Kühn, University of Graz, Graz, 8010, Styria, Austria

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.