Jiali Cao
Chenguang Shen
Wanting He- 1Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, China
- 2BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Guangzhou, China
- 3Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China
- 4Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States
Editorial on the Research Topic:
Molecular pathogenesis and control of viral infectious diseases in children
Pneumonia and diarrhoea are the leading infectious causes of childhood morbidity and mortality. According to the WHO, pneumonia killed 740 180 children under the age of 5 in 2019, accounting for 14% of all deaths of children under 5 years old but 22% of all deaths in children aged 1 to 5 years. Approximately 1.6 million deaths occur each year globally due to diarrhea and diarrhea contributed to 15% of all under-five deaths (Black et al., 2010; Collaborators G B D D D, 2018). This Research Topic focuses on viral infections leading to pneumonia and diarrhea, featuring contributions on severe pneumonia pathogens, the impact of COVID-19 on RSV prevalence, climate factors influencing influenza virus circulation, and the treatment of rotavirus-induced diarrhea.
Pneumonia, stemming from various infectious agents, necessitates accurate diagnosis, particularly in severe cases. Li et al. utilized metagenomic next-generation sequencing (mNGS) alongside conventional tests for pathogen detection in samples from Pediatric Intensive Care Unit (PICU) patients. The study underscores the importance of advanced diagnostic techniques, such as mNGS, for a deeper understanding of severe pneumonia’s microbial epidemiology in pediatric patients. mNGS can identify unknown or novel pathogens in a single test, Not limited to pre-assumed pathogens. The detection rate of mNGS is much higher than that of conventional methods, especially for the detection of bacteria, fungi and RNA viruses, but the false positive results of mNGS detection are still a problem that cannot be ignored. Although the detection results of mNGS can provide richer information than the traditional detection methods, the etiological diagnosis still needs to be combined with conventional methods, and professional judgement and treatment by clinicians.
The emergence of COVID-19 in recent years has significantly influenced the trends of other respiratory pathogens. Li et al. observed a marked decrease in Influenza virus and adenovirus cases among PICU pneumonia patients during the COVID-19 pandemic. Studies from different regions indicate that non-pharmaceutical interventions during the pandemic reduced the prevalence of various respiratory pathogens and experienced subsequent “upsurge” (Agca et al., 2021; Rodgers et al., 2021; Wan et al., 2021; Garg et al., 2022; Alaib et al., 2023; Yang et al., 2023; Zhang et al., 2023). Jiang et al. conducted an analysis of a prospective long-term cohort monitoring project in Suzhou, China, examining epidemiological and clinical data of 59,934 lower respiratory tract infection patients. The study investigates the resurgence of RSV infections after the initial wave of COVID-19, offering insights to guide preventive actions ahead of potential resurgences following the Omicron variant. Notably, the reduction in COVID-19-related measures led to a significant increase in RSV infections during the second year of the pandemic, emphasizing the need for vigilance.
Influenza remains a significant viral infection among children, with meteorological factors playing a crucial role in transmission. Chen et al. explored the impact of climate factors on influenza virus circulation in Guangzhou, China, along with the unique influence of COVID-19 and related control measures on two influenza epidemics.
Rotavirus, a common cause of diarrhea in infants and young children, disrupts the balance between the host system and gut microbiota. Xu et al. investigated the impact of zinc-containing combined treatment on the intestinal microbiome, revealing a reshaped flora structure and an increase in short-chain fatty acid-producing flora, potentially regulating the host immune response.
This Research Topic aims to enhance our understanding of viral infections in children and provide fresh perspectives for effective management. Throughout this Research Topic, we witness the dedication of scientists, doctors, and researchers to children’s health, actively contributing to the response to viral infectious disease challenges.
Author contributions
JC: Funding acquisition, Writing – original draft. CS: Writing – review & editing. WH: Writing – review & editing.
Funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by grants from the Medical and Health Guidance Project of Xiamen (3502Z20214ZD1223).
Acknowledgments
We thank all the contributors of this Research Topic and we wish you all a good reading.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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References
Agca, H., Akalin, H., Saglik, I., Hacimustafaoglu, M., Celebi, S., Ener, B.. (2021). Changing epidemiology of influenza and other respiratory viruses in the first year of covid-19 pandemic. J. Infect. Public Health 14 (9), 1186–1190. doi: 10.1016/j.jiph.2021.08.004
Alaib, H., Algariri, N., Ahmed, H., Bebars, A., Alamri, F., Durmush, R., et al. (2023). Frequency and seasonal variations of viruses causing respiratory tract infections in children pre- and post-covid-19 pandemic in riyadh (2017-2022). Cureus 15 (1), e33467. doi: 10.7759/cureus.33467
Black, R. E., Cousens, S., Johnson, H. L., Lawn, J. E., Rudan, I., Bassani, D. G., et al. (2010). Global, regional, and national causes of child mortality in 2008: A systematic analysis. Lancet [J] 375 (9730), 1969–1987. doi: 10.1016/S0140-6736(10)60549-1
Collaborators G B D D D (2018). Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: A systematic analysis for the global burden of disease study 2016. Lancet Infect. Dis. 18 (11), 1211–1228. doi: 10.1016/S1473-3099(18)30362-1
Garg, I., Shekhar, R., Sheikh, A. B., Pal, S. (2022). Impact of covid-19 on the changing patterns of respiratory syncytial virus infections. Infect. Dis. Rep. 14 (4), 558–568. doi: 10.3390/idr14040059
Rodgers, L., Sheppard, M., Smith, A., Dietz, S., Jayanthi, P., Yuan, Y., et al. (2021). Changes in seasonal respiratory illnesses in the United States during the coronavirus disease 2019 (covid-19) pandemic. Clin. Infect. Dis. 73 (Suppl 1), S110–S117. doi: 10.1093/cid/ciab311
Wan, W. Y., Thoon, K. C., Loo, L. H., Chan, K. S., Oon, L. L. E., Ramasamy, A., et al. (2021). Trends in respiratory virus infections during the covid-19 pandemic in Singapore, 2020. JAMA Netw. Open 4 (6), e2115973. doi: 10.1001/jamanetworkopen.2021.15973
Yang, M. C., Su, Y. T., Chen, P. H., Tsai, C. C., Lin, T. I., Wu, J. R. (2023). Changing patterns of infectious diseases in children during the covid-19 pandemic. Front. Cell Infect. Microbiol. 13. doi: 10.3389/fcimb.2023.1200617
Keywords: viral infectious, children, pneumonia, diarrhea, epidemiology
Citation: Cao J, Shen C and He W (2024) Editorial: Molecular pathogenesis and control of viral infectious diseases in children. Front. Cell. Infect. Microbiol. 14:1368324. doi: 10.3389/fcimb.2024.1368324
Received: 10 January 2024; Accepted: 25 January 2024;
Published: 02 February 2024.
Edited and Reviewed by:
Donghoon Chung, University of Louisville, United StatesCopyright © 2024 Cao, Shen and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jiali Cao, jialicao@xmu.edu.cn