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ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1361373

Exploring the gut microbiota's effect on Temporomandibular joint disorder: a two-sample Mendelian randomization analysis

Provisionally accepted
Kai Zhao Kai Zhao 1*Shuai qi Ji Shuai qi Ji 2Han Jiang Han Jiang 1,3Yun zhu Qian Yun zhu Qian 1,3Weibing Zhang Weibing Zhang 1,3
  • 1 Department of Stomatology, Suzhou Dushu Lake Hospital, Suzhou, China
  • 2 Fujian Key Laboratory of Oral Diseases & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University,, Fuzhou, Fujian Province, China
  • 3 Department of Stomatology, Suzhou Dushu Lake Hospital, Suzhou, Liaoning Province, China

The final, formatted version of the article will be published soon.

    Background: Temporomandibular joint disorders (TMD) are highly prevalent among people. Numerous investigations have revealed the impact of gut microbiota in many diseases. However, the causal relationship between Temporomandibular joint disorders and gut microbiota remains unclear.Methods: Genome-Wide Association Studies (GWAS) refer to the identification of sequence variations, namely single nucleotide polymorphisms (SNPs), existing across the entire human genome. GWAS data were collected on gut microbiota and TMD.Then, instrumental variables were screened through F-values and removal of linkage disequilibrium. These SNPs underwent mendelian analysis using five mathematical models. Sensitivity analysis was conducted to further verify the stability of the results. Pathogenic factors of TMD mediate the causal relationship between gut microbiota and TMD were explored through a two-step Mendelian randomization analysis.Finally, reverse mendelian analysis was conducted to account for potential reverse effects.The analysis of the data in this article suggests that some gut microbiota, including Coprobacter, Ruminococcus torques group, Catenibacterium, Lachnospiraceae, Turicibacter, Victivallis, MollicutesRF9, Methanobacteriales, Methanobacteriaceae, FamilyXI, Methanobacteria were identified as risk factors, while Peptococcaceae provides protection for TMD.The research reveals the relation of gut microbiota in TMD. These findings provide insights into the underlying mechanisms and suggest potential therapeutic strategy.

    Keywords: Gut Microbiota, temporomandibular joint disorder, Mendelian randomization, causal inference, Genetic Variation

    Received: 09 Jan 2024; Accepted: 19 Jul 2024.

    Copyright: © 2024 Zhao, Ji, Jiang, Qian and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kai Zhao, Department of Stomatology, Suzhou Dushu Lake Hospital, Suzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.