AUTHOR=Deng Ruiyi , Chen Xu , Zhao Shiqing , Zhang Qingying , Shi Yanyan 

TITLE=The effects and mechanisms of natural products on Helicobacter pylori eradication

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1360852

DOI=10.3389/fcimb.2024.1360852

ISSN=2235-2988

ABSTRACT=<p><italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) eradication is pivotal for alleviating gastric mucosal inflammation and preventing the progression of gastric diseases. While antibiotic-based therapies have achieved significant success in <italic>H. pylori</italic> eradication, challenges such as antibiotic resistance, drug toxicity, side effects, nonadherence, inapplicability, and disruption of gastrointestinal microflora have emerged. Updated therapies are urgently needed to suppress <italic>H. pylori</italic>. Nature has provided multitudinous therapeutic agents since ancient times. Natural products can be a potential therapy endowed with <italic>H. pylori</italic> eradication efficacy. We summarize the basic information, possible mechanisms, and the latest research progress of some representative natural products in <italic>H. pylori</italic> eradication, highlighting their safety, accessibility, efficiency, and ability to overcome limitations associated with antibiotic application. This review highlights the potential therapeutic advantages of incorporating ethnomedicine into anti-<italic>H. pylori</italic> regimens. The findings of this review may provide insights into the development of novel natural products and expand the therapeutic options available for <italic>H. pylori</italic> eradication.</p>