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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1357178

Progress in the study of the correlation between sepsis and intestinal microecology

Provisionally accepted
Yan-Lin Tao Yan-Lin Tao 1Jing Ran Wang Jing Ran Wang 2Miao Liu Miao Liu 3*Ya-Nan Liu Ya-Nan Liu 1*Jin-Qiu Zhang Jin-Qiu Zhang 4*Yi-Jing Zhou Yi-Jing Zhou 4*Shao-wei Li Shao-wei Li 5*Shu-Fen Zhu Shu-Fen Zhu 6*
  • 1 Department of Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China
  • 2 Department of Surgery ICU, Affiliated Hospital of Inner Mongolia Medical University, Hohht, China
  • 3 Department of Respiratory Medicine, Dingzhou People's Hospital, Dingzhou, China
  • 4 Department of Gastroenterology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang Province, China
  • 5 Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China
  • 6 Physical Examination Center, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China

The final, formatted version of the article will be published soon.

    Sepsis, a disease with high incidence, mortality, and treatment costs, has a complex interaction with the gut microbiota. With advances in high-throughput sequencing technology, the relationship between sepsis and intestinal dysbiosis has become a new research focus. However, owing to the intricate interplay between critical illness and clinical interventions, it is challenging to establish a causal relationship between sepsis and intestinal microbiota imbalance. In this review, the correlation between intestinal microecology and sepsis was summarized, and new therapies for sepsis intervention based on microecological target therapy were proposed, and the shortcomings of bacterial selection and application timing in clinical practice were addressed. In conclusion, current studies on metabolomics, genomics and other aspects aimed at continuously discovering potential probiotics are all providing theoretical basis for restoring intestinal flora homeostasis for subsequent treatment of sepsis.

    Keywords: Sepsis, Gut Microbiota, high-throughput sequencing, Inflammatory Response, immune suppression

    Received: 25 Dec 2023; Accepted: 03 Sep 2024.

    Copyright: © 2024 Tao, Wang, Liu, Liu, Zhang, Zhou, Li and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Miao Liu, Department of Respiratory Medicine, Dingzhou People's Hospital, Dingzhou, China
    Ya-Nan Liu, Department of Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China
    Jin-Qiu Zhang, Department of Gastroenterology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang Province, China
    Yi-Jing Zhou, Department of Gastroenterology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang Province, China
    Shao-wei Li, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China
    Shu-Fen Zhu, Physical Examination Center, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.