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CASE REPORT article

Front. Cell. Infect. Microbiol.
Sec. Antibiotic Resistance and New Antimicrobial drugs
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1354681
This article is part of the Research Topic Developments in non-antibiotic antimicrobials in the era of drug-resistant bacteria View all 10 articles

Case Report : Personalized triple phage-antibiotic combination therapy to rescue necrotizing fasciitis caused by Panton-Valentine Leukocidinproducing MRSA in a 12-year-old boy

Provisionally accepted
Brieuc Van Nieuwenhuyse Brieuc Van Nieuwenhuyse 1*Mathilde Balcaen Mathilde Balcaen 2Olga Chatzis Olga Chatzis 3Astrid Haenecour Astrid Haenecour 2Emilien Derycke Emilien Derycke 2Thierry Detaille Thierry Detaille 2Stéphan Clément De Cléty Stéphan Clément De Cléty 2Cecile Boulanger Cecile Boulanger 1,4,5Leïla Belkhir Leïla Belkhir 6,7Jean-Cyr Yombi Jean-Cyr Yombi 6Julien De Greef Julien De Greef 6,7Olivier Cornu Olivier Cornu 8,9Pierre-Louis Docquier Pierre-Louis Docquier 8,9Audrey Lentini Audrey Lentini 2Renaud Menten Renaud Menten 2Hector Rodriguez-Villalobos Hector Rodriguez-Villalobos 10,11Alexia Verroken Alexia Verroken 10,11Sarah Djebara Sarah Djebara 12Maia Merabishvili Maia Merabishvili 13Johann Griselain Johann Griselain 13Jean-Paul Pirnay Jean-Paul Pirnay 13Laurent Houtekie Laurent Houtekie 2Dimitri Van Der Linden Dimitri Van Der Linden 1,3
  • 1 Institute of Experimental and Clinical Research, Pediatric Department (IREC/PEDI), Université catholique de Louvain - UCLouvain, Brussels, Belgium
  • 2 Cliniques Universitaires Saint-Luc, Woluwe-Saint-Lambert, Belgium
  • 3 Pediatric Infectious Diseases, General Pediatrics Department, Cliniques universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium
  • 4 Genetics of Autoimmune Diseases and Cancer laboratoire,Université Catholique de Louvain, Brussels, Belgium
  • 5 Department of Pediatric Hematology and Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
  • 6 Division of Internal Medicine and Infectious Disease, Cliniques Universitaires Saint-Luc, Université catholique de Louvain - UCLouvain,, Brussels, Belgium
  • 7 Louvain centre for Toxicology and Applied Pharmacology, Institute for Experimental and Clinical Research,Université catholique de Louvain, Brussles, Belgium
  • 8 Service of Orthopedics and Traumatology of the Musculoskeletal System, Saint-Luc University Clinics, Brussels, Belgium
  • 9 Institut de recherche expérimentale et clinique, Faculté de pharmacie et des sciences biomédicales, Université catholique de Louvain, Brussels, Belgium
  • 10 Department of Microbiology, Cliniques universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium
  • 11 Institute of Experimental and Clinical Research, Medical Microbiology Department (IREC/MBLG), Université catholique de Louvain - UCLouvain, Brussels, Belgium
  • 12 Center for Infectious Diseases, Queen Astrid Military Hospital, Brussels, Belgium
  • 13 Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium

The final, formatted version of the article will be published soon.

    Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant Staphylococcus aureus (MRSA) in a 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against Staphylococcus aureus, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, eventually leading to full recovery with no reported adverse events.

    Keywords: MRSA, Panton and Valentine leukocidin (PVL), Bacteriophage, phage therapy, Necrotizing fasciitis, pediatric intensive care unit

    Received: 12 Dec 2023; Accepted: 26 Aug 2024.

    Copyright: © 2024 Van Nieuwenhuyse, Balcaen, Chatzis, Haenecour, Derycke, Detaille, Clément De Cléty, Boulanger, Belkhir, Yombi, De Greef, Cornu, Docquier, Lentini, Menten, Rodriguez-Villalobos, Verroken, Djebara, Merabishvili, Griselain, Pirnay, Houtekie and Van Der Linden. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Brieuc Van Nieuwenhuyse, Institute of Experimental and Clinical Research, Pediatric Department (IREC/PEDI), Université catholique de Louvain - UCLouvain, Brussels, Belgium

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