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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1341953

Study on the effects of intestinal flora on gouty arthritis

Provisionally accepted
Niqin Xiao Niqin Xiao 1Zhang Xiaoyu Zhang Xiaoyu 2Yujiang Xi Yujiang Xi 1Zhenmin Li Zhenmin Li 1*Yuanyuan Wei Yuanyuan Wei 2Jiayan Shen Jiayan Shen 2*Lin Wang Lin Wang 2*Dongdong Qin Dongdong Qin 2*zhaohu xie zhaohu xie 2*zhaofu li zhaofu li 2*
  • 1 yunnan university of traditional medicine, 昆明市, China
  • 2 Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China

The final, formatted version of the article will be published soon.

    Gouty arthritis (GA), a metabolic and immunologic disease, primarily affects joints.Dysbiosis of intestinal flora is an important cause of GA. The metabolic disorders of intestinal flora leading to GA and immune disorders might play an important role in patients with hyperuricemia and established GA. However, the exact mechanisms, through which the dysbiosis of intestinal flora causes the development of GA, are not fully understood yet. Moreover, several therapies commonly used to treat GA might alter the intestinal flora, suggesting that modulation of the intestinal flora might help prevent or treat GA. Therefore, a better understanding of the changes in the intestinal flora of GA patients might facilitate the discovery of new diagnostic and therapeutic approaches. The current review article discusses the effects of intestinal flora dysbiosis on the pathogenesis of GA and the cross-regulatory effects between gut flora and drugs for treating GA. This article also highlights the modulatory effects of gut flora by traditional Chinese medicine (TCM) to lower uric acid levels and relieve joint pain as well as provides a summary and outlook, which might help guide future research efforts.

    Keywords: Gouty arthritis, intestinal flora, Pathogenesis, Drug Therapy, Traditional Chinese Medicine

    Received: 24 Nov 2023; Accepted: 22 Jul 2024.

    Copyright: © 2024 Xiao, Xiaoyu, Xi, Li, Wei, Shen, Wang, Qin, xie and li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhenmin Li, yunnan university of traditional medicine, 昆明市, China
    Jiayan Shen, Yunnan University of Traditional Chinese Medicine, Kunming, 650500, Yunnan Province, China
    Lin Wang, Yunnan University of Traditional Chinese Medicine, Kunming, 650500, Yunnan Province, China
    Dongdong Qin, Yunnan University of Traditional Chinese Medicine, Kunming, 650500, Yunnan Province, China
    zhaohu xie, Yunnan University of Traditional Chinese Medicine, Kunming, 650500, Yunnan Province, China
    zhaofu li, Yunnan University of Traditional Chinese Medicine, Kunming, 650500, Yunnan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.