AUTHOR=Kuenzli Andrea B. , Müller Mandy D. , Z`Graggen Werner J. , Walti Laura N. , Martin Yonas , Lazarevic Vladimir , Schrenzel Jacques , Oberli Alexander 

TITLE=Case report: Chronic Candida albicans meningitis: a rare entity diagnosed by metagenomic next-generation sequencing

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1322847

DOI=10.3389/fcimb.2024.1322847

ISSN=2235-2988

ABSTRACT=<p>The aetiology of chronic aseptic meningitis is difficult to establish. <italic>Candida</italic> meningitis in particular is often diagnosed late, as cerebrospinal fluid (CSF) work-up and imaging findings are nonspecific. A 35-year-old patient with chronic aseptic meningitis, for which repeated microbiological testing of CSF was unrevealing, was finally diagnosed with <italic>Candida albicans (C. albicans)</italic> meningitis with cauda equina involvement using metagenomic next-generation sequencing (mNGS). This report highlights the diagnostic challenges and the difficulties of treating shunt-associated fungal meningitis.</p>