AUTHOR=Silva Marcos Jessé Abrahão , Vieira Marcelo Cleyton da Silva , Souza Alex Brito , Santos Everaldina Cordeiro dos , Marcelino Beatriz dos Reis , Casseb Samir Mansour Moraes , Lima Karla Valéria Batista , Lima Luana Nepomuceno Gondim Costa 

TITLE=Analysis of associations between the TLR3 SNPs rs3775291 and rs3775290 and COVID-19 in a cohort of professionals of Belém-PA, Brazil

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1320701

DOI=10.3389/fcimb.2023.1320701

ISSN=2235-2988

ABSTRACT=<p>The objective of this article was to verify associations between the SNPs rs3775291 (Cytosine [C]&gt;Thymine [T]) and rs3775290 (C&gt;T) of <italic>TLR3</italic> in professionals from Health Institutions (HI) who worked during the first pandemic wave and COVID-19. A case-control study was carried out with workers from HI in Belém-PA, Brazil, divided into symptomatology groups (Asymptomatic-AS, <italic>n</italic>=91; and Symptomatic-SI, <italic>n</italic>=121), and severity groups, classified by Chest CT scan (symptomatic with lung involvement – SCP, <italic>n</italic>=34; symptomatic without lung involvement – SSP, <italic>n</italic>=8). Genotyping was performed by Sanger sequencing and statistical analysis was performed using the SPSS program. In the analysis of SNP rs3775291, the homozygous recessive genotype (T/T) was not found and the frequency of the mutant allele (T) was less than 2% in the cohort. For the rs3775290 SNP, the frequency of the mutant allele (T) was greater than 42% in the cohort. No significant associations were found for these SNPs in this cohort (N= 212 individuals). The scientific community and physicians can use these facts to find new methods of managing COVID-19.</p>