AUTHOR=Liu Jiajiao , Xu Zhaoxia , Bai Yujie , Feng Jian , Xu Lunshan , Li Fuxiang 

TITLE=Streptomyces albireticuli lung infection managed as a pulmonary air cyst: a case report and literature review

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=13

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1296491

DOI=10.3389/fcimb.2023.1296491

ISSN=2235-2988

ABSTRACT=<p><italic>Streptomyces</italic>, the largest genus in the <italic>Streptomycetaceae</italic> family and a prolific producer of antibacterial drugs, is a saprophytic soil organism that rarely causes invasive infections. Here we report a case of necrotic pneumonia caused by <italic>Streptomyces albireticuli</italic> in a 75-year-old man who presented with progressive chest tightness and dyspnea. <italic>Streptomyces albireticuli</italic> was isolated from his bronchoalveolar lavage fluid and identified through whole-genome sequencing (WGS) and phylogenetic analysis. The patient responded satisfactorily to clarithromycin therapy. The findings of this study may enhance our vigilance in identifying visceral infections caused by <italic>Streptomyces</italic>.</p>