AUTHOR=Lussac-Sorton Florian , Charpentier Éléna , Imbert Sébastien , Lefranc Maxime , Bui Stéphanie , Fayon Michael , Berger Patrick , Enaud Raphaël , Delhaes Laurence TITLE=The gut-lung axis in the CFTR modulator era JOURNAL=Frontiers in Cellular and Infection Microbiology VOLUME=13 YEAR=2023 URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1271117 DOI=10.3389/fcimb.2023.1271117 ISSN=2235-2988 ABSTRACT=

The advent of CFTR modulators represents a turning point in the history of cystic fibrosis (CF) management, changing profoundly the disease’s clinical course by improving mucosal hydration. Assessing changes in airway and digestive tract microbiomes is of great interest to better understand the mechanisms and to predict disease evolution. Bacterial and fungal dysbiosis have been well documented in patients with CF; yet the impact of CFTR modulators on microbial communities has only been partially deciphered to date. In this review, we aim to summarize the current state of knowledge regarding the impact of CFTR modulators on both pulmonary and digestive microbiomes. Our analysis also covers the inter-organ connections between lung and gut communities, in order to highlight the gut-lung axis involvement in CF pathophysiology and its evolution in the era of novel modulators therapies.