AUTHOR=Chen Yi , Yang Chaoyu , You Ningning , Zhang Jinshun 

TITLE=Relationship between Helicobacter pylori and glycated hemoglobin: a cohort study

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1196338

DOI=10.3389/fcimb.2023.1196338

ISSN=2235-2988

ABSTRACT=<sec><title>Background</title><p><italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) has increasingly been shown to be related to extragastric diseases. Glycated hemoglobin A1c (HbA1c), an indicator of glycemic control, is closely linked to the event of diabetes. The purpose of this research was to analyze the association between <italic>H. pylori</italic> and HbA1c through a cohort study.</p></sec><sec><title>Methods</title><p>The population who underwent multiple physical checkups in the physical examination center of Taizhou Hospital was included. All of them underwent urea breath test, serological examination and physical parameter measurement. Multiple regression was used for analyzing the influencing factors of HbA1c. In addition, the result of HbA1c on <italic>H. pylori</italic> infection was studied by restricted cubic spline (RCS) analysis. The triglyceride glucose (TyG) index represents the level of insulin resistance (IR) in the population. The population was classified on the basis of primary and last <italic>H. pylori</italic> infection, therefore, the variations of HbA1c and TyG index among totally different teams were investigated.</p></sec><sec><title>Results</title><p>Multiple regression demonstrated that <italic>H. pylori</italic> was an influential factor in HbA1c. RCS analysis showed a nonlinear relationship between HbA1c and <italic>H. pylori</italic> infection. When HbA1c&gt;5.7%, the chance of <italic>H. pylori</italic> infection was considerably enlarged. Additionally, long-term <italic>H. pylori</italic> infection increased HbA1c levels, while HbA1c levels decreased after <italic>H. pylori</italic> eradication. Similarly, long-term <italic>H. pylori</italic> infection also increased the TyG index.</p></sec><sec><title>Conclusion</title><p>Prediabetes increases the danger of <italic>H. pylori</italic> infection, long-term <italic>H. pylori</italic> infection increases HbA1c and IR levels, and wipeout of <italic>H. pylori</italic> could have a positive impact for glycemic control in the population.</p></sec>