AUTHOR=Kayongo Alex , Nyiro Brian , Siddharthan Trishul , Kirenga Bruce , Checkley William , Lutaakome Joloba Moses , Ellner Jerrold , Salgame Padmini 

TITLE=Mechanisms of lung damage in tuberculosis: implications for chronic obstructive pulmonary disease

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1146571

DOI=10.3389/fcimb.2023.1146571

ISSN=2235-2988

ABSTRACT=<p>Pulmonary tuberculosis is increasingly recognized as a risk factor for COPD. Severe lung function impairment has been reported in post-TB patients. Despite increasing evidence to support the association between TB and COPD, only a few studies describe the immunological basis of COPD among TB patients following successful treatment completion. In this review, we draw on well-elaborated <italic>Mycobacterium tuberculosis</italic>-induced immune mechanisms in the lungs to highlight shared mechanisms for COPD pathogenesis in the setting of tuberculosis disease. We further examine how such mechanisms could be exploited to guide COPD therapeutics.</p>